摘要
目的:探究长链非编码核糖核酸(Long noncoding RNA,LncRNA)转移相关肺腺癌转录本1(Metastasis associated lung adenocarcinoma transcript 1,MALAT1)与外周血炎症复合指标在非小细胞肺癌(Non-small cell lung cancer,NSCLC)发生淋巴结转移之间的相关性。方法:选取2022年3月至2025年2月期间在我院心胸外科就诊的120例T1期NSCLC患者作为研究对象,按照患者是N1期还是N0期将其分为转移组(n=26)和非转移组(n=94)。对比两组患者在LncRNA MALAT1以及外周血炎症复合指标方面的差异,检测各个指标在诊断NSCLC发生纵隔淋巴结转移方面的效能,同时检测LncRNA MALAT1与外周血炎症复合指标之间的相关性。结果:转移组患者术前的血清LncRNA MALAT1水平、中性粒细胞与淋巴细胞比率(Neutrophil-to-lymphocyte,NLR)、血小板与淋巴细胞比率(Platelet-to-lymphocyte,PLR)均明显高于非转移组(P<0.05),转移组患者术前的淋巴细胞与单核细胞比率(Lymphocyte-to-monocyte,LMR)明显低于非转移组(P<0.05)。在受试者工作特征曲线(Receiver operating characteristic curve,ROC)中,LncRNA MALAT1的曲线下面积(Area under the curve,AUC)为0.9124(95%置信区间(Confidence interval,CI)=0.8593~0.9656),NLR的AUC为0.9358(95%CI=0.8905~0.9810),LMR的AUC为0.8601(95%CI=0.7801~0.9400),PLR的AUC为0.8187(95%CI=0.7116~0.9258),对NSCLC淋巴结转移均具有较高诊断效能。转移组患者术前血清LncRNA MALAT1水平与NLR、LMR以及PLR水平均呈正相关(P<0.05)。结论:LncRNA MALAT1与外周血炎症复合指标在预测T1期NSCLC发生淋巴结转移方面具备良好的诊断效能,同时LncRNA MALAT1与外周血炎症复合指标之间呈正相关。
Objective:To explore the correlation between long noncoding RNA(LncRNA)metastasis associated lung adenocarcinoma transcript 1(MALAT1)and peripheral blood inflammatory composite indicators in lymph node metastasis of non-small cell lung cancer(NSCLC).Methods:A total of 120 patients with stage T1 NSCLC who visited the Department of Cardiothoracic Surgery in our hospital from March 2022 to February 2025 were selected as the research subjects.They were divided into the metastasis group(n=26)and the non-metastasis group(n=94)according to whether they were in stage N1 or N0.The differences in LncRNA MALAT1 and peripheral blood inflammatory composite indicators between the two groups were compared.The efficacy of each indicator in diagnosing mediastinal lymph node metastasis of NSCLC was detected.Meanwhile,the correlation between LncRNA MALAT1 and peripheral blood inflammatory composite indicators was detected.Results:The preoperative serum levels of LncRNA MALAT1,neutrophil-to-lymphocyte ratio(NLR),and platelet-to-lymphocyte ratio(PLR)in the metastasis group were significantly higher than those in the non-metastasis group(P<0.05),and the preoperative lymphocyte-to-monocyte ratio(LMR)in the metastasis group was significantly lower than that in the non-metastasis group(P<0.05).In the receiver operating characteristic curve(ROC),the area under the curve(AUC)of LncRNA MALAT1 was 0.9124(95%confidence interval(CI)=0.8593-0.9656),the AUC of NLR was 0.9358(95%CI=0.8905-0.9810),the AUC of LMR was 0.8601(95%CI=0.7801-0.9400),and the AUC of PLR was 0.8187(95%CI=0.7116-0.9258),all of which had high diagnostic efficacy for NSCLC lymph node metastasis.The preoperative serum level of LncRNA MALAT1 in the metastasis group was positively correlated with the levels of NLR,LMR,and PLR(P<0.05).Conclusion:LncRNA MALAT1 and peripheral blood inflammatory composite indicators have good diagnostic efficacy in predicting lymph node metastasis of stage T1 NSCLC,and there is a positive correlation between LncRNA MALAT1 and peripheral blood inflammatory composite indicators.
作者
豆永辉
于桢
朱国玺
Dou Yong-hui;Yu Zhen;Zhu Guo-xi(Department of Cardiothoracic Surgery,Central Hospital of Jiaozuo Coal Industry(Group)Co.LTD,Jiaozuo 454150,Henan,China)
关键词
LncRNA
MALAT1
外周血炎症复合指标
非小细胞肺癌
纵隔淋巴结转移
Long noncoding RNA metastasis associated lung adenocarcinoma transcript 1
Peripheral blood inflammatory composite indicators
Non-small cell lung cancer
Mediastinal lymph node metastasis
