摘要
颈源性头痛(cervicogenic headache,CEH)是一种由颈椎或颈部软组织病变引起的头面部牵涉痛,因其临床表现常与其他类型头痛重叠,且缺乏特异性生物学标志物,致使诊断存在困难。目前,对CEH神经机制的认识仍不足,亟需系统梳理相关影像学研究进展,以推动其精准诊疗。静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)能够无创揭示大脑自发神经活动与功能连接变化,已成为探索CEH中枢重塑特征的重要工具。本文对近年来rs-fMRI在CEH领域的研究进行系统综述,总结其在揭示脑功能异常模式、辅助鉴别诊断等方面的应用进展,并指出现有研究在样本规模、机制纵深及临床转化方面仍存在局限,未来需结合多模态影像与纵向设计进一步深入。本文旨在整合现有证据,深化对CEH中枢机制的理解,为rs-fMRI在CEH中的研究提供参考。
Cervicogenic headache(CEH)is a type of head and facial pain caused by disorders of the cervical spine or cervical soft tissues.Its clinical manifestations often overlap with other types of headaches,and the lack of specific biological markers makes diagnosis challenging.At present,understanding of its neural mechanisms remains insufficient,and there is an urgent need to systematically review related imaging research progress to promote accurate diagnosis and treatment.Resting-state functional magnetic resonance imaging(rs-fMRI)can non-invasively reveal spontaneous brain neural activity and changes in functional connectivity and has become an important tool for exploring central remodeling features in CEH.This article provides a systematic review of recent rs-fMRI research in the field of CEH,summarizing its application progress in revealing patterns of brain dysfunction and assisting in differential diagnosis,while pointing out that existing studies still have limitations in sample size,mechanistic depth,and clinical translation.Future research needs to further explore these aspects by integrating multimodal imaging and longitudinal designs.This article aims to integrate existing evidence,deepen the understanding of the central mechanism of CEH,and provide a reference for the research of rs-fMRI in CEH.
作者
张天龙
宋敏
张彦军
宋永嘉
ZHANG Tianlong;SONG Min;ZHANG Yanjun;SONG Yongjia(Gansu University of Chinese Medicine,School of Traditional Chinese Clinical Medicine,Lanzhou 730030,China;Department of Spine and BoneⅡ,Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China)
出处
《磁共振成像》
北大核心
2026年第2期147-153,共7页
Chinese Journal of Magnetic Resonance Imaging
基金
国家自然科学基金地区项目(编号:82460943)
国家中医药管理局-重大疑难疾病中西医临床协作项目(编号:ZDYN-2024-A-145)
兰州市科技发展指导性计划项目(编号:2023-ZD-46)。
关键词
颈源性头痛
慢性疼痛
中枢敏化
磁共振成像
功能连接
脑网络
cervicogenic headache
chronic pain
central sensitization
magnetic resonance imaging
functional connectivity
brain networks
