摘要
目的探讨血清S100钙结合蛋白B(S100B)、脂蛋白相关磷脂酶A_(2)(Lp-PLA_(2))水平与老年急性进展性脑梗死患者颈动脉斑块稳定性的关系。方法82例老年急性进展性脑梗死患者均有颈动脉斑块,其中易损斑块39例,稳定斑块43例。比较不同颈动脉斑块性质患者的临床特征,分析影响老年急性进展性脑梗死患者颈动脉斑块稳定性的危险因素。绘制ROC曲线分析血清S100B、Lp-PLA_(2)水平单独及联合检测对老年急性进展性脑梗死患者颈动脉易损斑块的诊断价值。结果与稳定斑块患者比较,易损斑块患者吸烟比例、美国国立卫生院卒中量表评分、LDL-C、同型半胱氨酸、超敏CRP、S100B及Lp-PLA_(2)水平均升高(P<0.01)。血清S100B、Lp-PLA_(2)水平升高是影响老年急性进展性脑梗死患者颈动脉斑块稳定性的独立危险因素(P<0.05)。联合检测血清S100B、Lp-PLA_(2)水平诊断老年急性进展性脑梗死患者颈动脉易损斑块的AUC、灵敏度、特异度分别为0.962、82.10%、95.30%,均高于二者单独检测(P<0.05)。结论血清S100B、Lp-PLA_(2)水平与老年急性进展性脑梗死患者颈动脉斑块稳定性的关系密切。联合检测血清S100B、Lp-PLA_(2)水平有助于诊断老年急性进展性脑梗死患者颈动脉易损斑块。
Objective To explore the relationship between serum levels of S100 calcium-binding protein B(S100B)and lipoprotein-associated phospholipase A_(2)(Lp-PLA_(2))and the stability of carotid plaques in elderly patients with acute progressive cerebral infarction.Methods All 82 elderly patients with acute progressive cerebral infarction had carotid plaques,including 39 cases with vulnerable plaques and 43 cases with stable plaques.The clinical characteristics of patients with different types of carotid plaques were compared,and the risk factors influencing the stability of carotid plaques in elderly patients with acute progressive cerebral infarction were analyzed.ROC curves were drawn to analyze the diagnostic value of serum levels of S100B and Lp-PLA_(2)alone and in combination for vulnerable carotid plaques in elderly patients with acute progressive cerebral infarction.Results Compared with patients with stable plaques,the smoking rate,National Institutes of Health Stroke Scale score,LDL-C,homocysteine,high-sensitivity CRP,S100B and Lp-PLA_(2)in patients with vulnerable plaques were all increased(P<0.01).Increased serum levels of S100B and Lp-PLA_(2)were independent risk factors influencing carotid plaque stability in elderly patients with acute progressive cerebral infarction(P<0.05).The AUC,sensitivity and specificity of combined detection of serum levels of S100B and Lp-PLA_(2)in diagnosing vulnerable carotid plaques in elderly patients with acute progressive cerebral infarction were 0.962,82.10%and 95.30%,respectively,which were all higher than those detected separately(P<0.05).Conclusion The serum levels of S100B and Lp-PLA_(2)are closely related to carotid plaque stability in elderly patients with acute progressive cerebral infarction.The combined detection of serum levels of S100B and Lp-PLA_(2)is helpful for diagnosing vulnerable carotid plaques in elderly patients with acute progressive cerebral infarction.
作者
马艳茹
任红艳
马雅茹
陈桂生
高瑜
MA Yanru;REN Hongyan;MA Yaru;CHEN Guisheng;GAO Yu(Department of Neurology,Ningxia Integrated Traditional Chinese and Western Medicine Hospital,Yinchuan 750011,China;Department of Neurology,General Hospital of Ningxia Medical University,Yinchuan 750004,China;Department of Health Mangement Center,Peking University First Hospital Ningxia Women and Children s0x09 Hospital,Yinchuan 750000,China)
出处
《江苏医药》
2026年第1期24-28,共5页
Jiangsu Medical Journal
