摘要
目的探讨全身免疫炎症指数(SⅡ)及超敏C反应蛋白(hs-CRP)与急性阑尾炎严重程度的相关性。方法回顾性分析2023年1月1日至2024年12月31日于南京市江宁医院就诊的335例急性阑尾炎手术患者临床资料,根据临床表现及病理结果,将患者分为简单阑尾炎组(n=181)与复杂阑尾炎组(n=154),并选取同期100例健康体检人员作为对照组。收集各组术前白细胞计数(WBC)、淋巴细胞计数(Lym)、中性粒细胞计数(Neu)、血小板计数(PLT)、hs-CRP等,SⅡ通过公式(PLT×Neu/Lym)计算得出,比较各组不同指标间差异,采用Spearman分析急性阑尾炎患者SⅡ与hs-CRP之间的相关性,利用受试者工作特征(ROC)曲线评估SⅡ与hs-CRP指标对急性阑尾炎严重程度的预测价值。结果hs-CRP、WBC及SⅡ在急性阑尾炎不同严重程度中均有一定的差异,且两者与SⅡ之间均有相关性(r=0.524、0.491,P<0.05)。SⅡ与hs-CRP联合检测相对于血常规及hs-CRP单项检测对复杂阑尾炎更具有诊断价值,联合检测曲线下面积为0.796(95%CI:0.705~0.835),灵敏度为73.55%,特异度为73.48%(P<0.01)。结论SⅡ和hs-CRP对急性阑尾炎的严重程度均有较好的预测价值,且联合检测对于诊断复杂阑尾炎有积极意义。
Objective To explore the correlation between the systemic immune inflammatory index(SⅡ)and hypersensitive C-reactive protein(hs-CRP)with the severity of acute appendicitis.Methods The clinical data of 335 patients who underwent surgery for acute appendicitis at Nanjing Jiangning Hospital from January 1,2023 to December 31,2024 were retrospectively analyzed.According to clinical manifestations and pathological findings,the patients were divided into the simple appendicitis group(n=181)and the complicated appendicitis group(n=154).Additionally,100 healthy individuals who underwent physical examinations during the same period were selected as the control group.Preoperative total white blood cell count(WBC),lymphocyte count(Lym),neutrophil count(Neu),platelet count(PLT),and hs-CRP were collected in each group.The SⅡwas calculated using the formula(PLT×Neu/Lym).Differences in various indicators among the groups were compared.Spearman analysis was used to assess the correlation between SⅡand hs-CRP in patients with acute appendicitis,and receiver operating characteristic(ROC)curves were used to evaluate the predictive value of SⅡand hs-CRP for the severity of acute appendicitis.Results hs-CRP,WBC,and SⅡshowed certain differences among different severity levels of acute appendicitis.Both hs-CRP and WBC were correlated with SⅡ(r=0.524,0.491,P<0.05).The combined detection of SⅡand hs-CRP showed higher diagnostic value for complicated appendicitis compared to either complete blood count or hs-CRP alone,with an area under the curve of 0.796(95%CI:0.705-0.835),asensitivity of 73.55%,and aspecificity of 73.48%(P<0.01).Conclusion Both SⅡand hs-CRP have a good predictive value for the severity of acute appendicitis,and combined detection has positive significance for the diagnosis of complicated appendicitis.
作者
汪静
陈莉
赵润鹏
于慧
张浩
韩亚飞
WANG Jing;CHEN Li;ZHAO Runpeng;YU Hui;ZHANG Hao;HAN Yafei(Department of Clinical Laboratory,The Affiliated Jiangning Hospital of Nanjing Medical University,Nanjing,Jiangsu 211100,China;不详)
出处
《中国临床研究》
2026年第1期107-110,共4页
Chinese Journal of Clinical Research
基金
安徽省高校自然科学研究项目(KJ2019A0276)。
关键词
急性阑尾炎
复杂阑尾炎
白细胞计数
全身免疫炎症指数
超敏C反应蛋白
Acute appendicitis
Complicated appendicitis
White blood cell count
Systemic immune inflammatory index
Hypersensitive C-reactive protein
