摘要
归纳总结丹参及其活性成分治疗脑小血管病(CSVD)相关步态障碍的药理机制。CSVD是一种缓慢进展的脑部血管疾病,其引起的相关步态障碍严重影响患者的生活质量。丹参作为治疗脑血管疾病的常用药物,具有活血化瘀、清热凉血、除烦安神之功效,可通过多靶点、多途径治疗CSVD引起的步态障碍,延缓步态异常进展。丹参中丹参酮类(丹参酮Ⅰ、丹参酮ⅡA、隐丹参酮)、酚酸类(咖啡酸、阿魏酸、丹酚酸)、丹参素类、黄酮类及多糖类等有效成分具有改善脑部微循环、抗氧化反应、抗炎症反应、保护血管内皮、抗血小板聚集和抑制血栓形成的作用。
This review summarizes the pharmacological mechanisms by which Danshen(Salvia miltiorrhiza)and its active components treat gait impairment associated with cerebral small vessel disease(CSVD).CSVD is a slowly progressive cerebrovascular disorder,and related gait disturbances significantly affect patients'quality of life.As a commonly used agent in cerebrovascular diseases,Danshen(Salvia miltiorrhiza)promotes blood circulation,removes blood stasis,clears heat,cools the blood,alleviates irritability,and calms the mind.It acts through multiple targets and pathways to treat CSVD-induced gait impairment and delay the progression of gait abnormalities.Active components such as tanshinones(including tanshinoneⅠ,tanshinoneⅡA,cryptotanshinone),phenolic acids(such as caffeic acid,ferulic acid,salvianolic acids),danshensu,flavonoids,and polysaccharides improve cerebral microcirculation,exert antioxidant and anti-inflammatory effects,protect vascular endothelium,inhibit platelet aggregation,and suppress thrombus formation.
作者
王夏
杜松
侯唯一
范佩娟
金亚妮
刘燕妮
WANG Xia;DU Song;HOU Weiyi;FAN Peijuan;JIN Yani;LIU Yanni(Shaanxi University of Chinese Medicine,Xianyang Shaanxi 712046,China;The Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang Shaanxi 712000,China)
出处
《中医药导报》
2026年第1期154-160,共7页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
陕西省科技厅重点研发计划项目(2024SF-YBXM-503)
国家中医药管理局临床研究课题(lcyj20200913)。
关键词
丹参
脑小血管病
步态异常
药理机制
综述
Danshen(Salvia miltiorrhiza)
cerebral small vessel disease
gait abnormality
pharmacological mechanism
review
