摘要
In this study, we outline a versatile method for the preparation of trifluoromethyl-containing unsymmetrical disulfides via catalytic photoredox difunctionalization of alkenes using symmetrical tetrasulfide (RSSSSR) and Langlois' reagent (CF₃SO₂Na). Notably, this method is also suitable for the late-stage modification of pharmaceutical molecule derivatives. Furthermore, a set of experimental investigations, such as radical trapping experiment, scrambling experiment, cyclic voltammetry (CV) measurement, Stern-Volmer analysis, on/off light-control experiments and a radical cascade experiment have been performed to support the photocatalytic reductive quenching cycle and radical-radical coupling reaction pathway.
基金
supported by the Special Projects in Key Fields of Colleges and Universities in Guangdong Province(2024ZDZX2078)
the Basic and Applied Basic Research Fund Project of Guangdong Province(2023A1515110852)
Special Funds of Key Disciplines Construction from Guangdong and Zhongshan Cooperating.
