摘要
In this study,electrochemical C-H carboxylation of benzylamines with CO_(2) was reported.This linear paired electrolysis system enables efficient and economical synthesis of value-added α-amino acids(α-AAs) under mild conditions.Various substituted benzylamines containing diverse functional groups and even highly reactive moieties,such as cyano,amide and alkene groups could be successfully transformed to the carboxylated products.Notably,this method proved to be applicable to the late-stage modification of biorelevant compounds,highlighting its potential for synthetic chemistry.Mechanistic studies such as radical trapping experiments,kinetic isotope effect(KIE) tests and cyclic voltammetry(CV) studies provided useful insight into this transformation.
基金
Financial support from National Key R&D Program of China (No.2023YFA1507203)
National Natural Science Foundation of China (Nos.22371149 and 22188101)
the Fundamental Research Funds for the Central Universities (No.63224098)
Frontiers Science Center for New Organic Matter,Nankai University (No.63181206)
Nankai University are gratefully acknowledged
the Haihe Laboratory of Sustainable Chemical Transformations for financial support。
