摘要
目的:探讨吡拉西坦联合尼莫地平对脑梗死后血管性痴呆(VD)患者认知功能及生活能力的影响。方法:选取2023年1月—2024年6月我院收治的78例脑梗死后VD患者,随机分为两组,对照组仅接受尼莫地平治疗,观察组则在尼莫地平的基础上加用吡拉西坦,比较两组患者的临床疗效、神经及认知功能指标、生活质量。结果:观察组的疗效显著,其治疗有效率为94.87%,显著高于对照组的71.79%(P<0.05);治疗后,相较于对照组,观察组的NIHSS(美国国立卫生研究院卒中量表)评分显著降低,MMSE(简易精神状态检查)评分、ADL(生活活动能力)评分则显著升高(P<0.05);在生活质量方面,与对照组治疗后相比,观察组的GQOLI-74评分均显著提高(P<0.05)。结论:吡拉西坦联合尼莫地平治疗脑梗死后VD的效果显著,不仅能有效改善患者的认知功能,还能提高其生活自理能力和整体生活质量。
Objective:To explore the effect of piracetam combined with nimodipine on cognitive function and living ability of patients with vascular dementia after cerebral infarction.Methods:From January 2023 to June 2024,78 patients with vascular dementia after cerebral infarction treated in our hospital were randomly divided into two groups.The control group received nimodipine only,while the observation group added piracetam to nimodipine.The clinical efficacy,neurological and cognitive function indexes and quality of life of the two groups were compared.Results:The efficacy of the observation group was significant,with the effective rate reaching 94.87%,which was significantly higher than 71.79%of the control group(P<0.05).After treatment,the NIHSS score of the observation group decreased significantly compared with the control group,while the MMSE score and ADL score were significantly increased(P<0.05).In terms of quality of life,the GQOLI-74 scores were significantly improved in the observation group compared with the control group after treatment(P<0.05).Conclusion:Piracetam combined with nimodipine is effective in treating vascular dementia after cerebral infarction,which can effectively improve cognitive function,self-care ability and quality of life.
作者
钟胜喜
ZHONG Shengxi(Hong'an Hospital Affiliated to Wuhan University of Science and Technology,Huanggang,Hubei 438400,China)
出处
《中国科技论文在线精品论文》
2025年第4期435-437,共3页
Highlights of Sciencepaper Online
关键词
神经病学
脑梗死后血管性痴呆
吡拉西坦
尼莫地平
认知功能
生活能力
neurology
vascular dementia after cerebral infarction
piracetam
nimodipine
cognitive function
living ability
