摘要
迁移体(migrasomes)是近年来发现的一种新型细胞器,它是一种由迁移中的细胞产生的、富含四跨膜蛋白的囊泡状结构。虽在形态上同为囊泡,但迁移体在形成机制和功能上显著区别于外泌体等其他细胞外囊泡,并最终被释放到细胞外环境中。迁移体形成主要依赖于细胞迁移过程中收缩纤维的断裂,其内部富含多种信号分子、蛋白质和RNA,在细胞间通信、发育调控和疾病进程中发挥重要作用。鉴于这些关键功能,迁移体已成为理解生命过程及开发临床疗法的潜在新靶点。然而,虽然其产生与功能研究已取得初步进展,但在相关疾病发生发展中的具体作用机制,以及迁移体作为诊断标志物或治疗靶向的潜在价值,仍亟待深入探索与梳理。为此,该文旨在综述迁移体在疾病研究中的最新进展,对其在疾病中的作用提供系统性总结,并为其作为疾病诊断标志物或治疗靶点的潜在应用提供理论依据。
Migrasomes are newly discovered organelles defined as tetraspanin-enriched vesicular structures produced by migrating cells.Although morphologically similar to vesicles,migrasomes are distinct from other extracellular vesicles,such as exosomes,in their biogenesis mechanisms and functions,and are ultimately released into the extracellular space.The formation of migrasomes primarily depends on the breakage of retraction fibers during cell migration.These structures are enriched with various signaling molecules,proteins,and RNA,enabling them to play crucial roles in intercellular communication,developmental regulation,and disease processes.Given these critical functions,migrasomes have emerged as a potential novel target for understanding fundamental biological processes and developing clinical therapies.However,despite preliminary progress in understanding their biogenesis and functions,the specific mechanisms of action in the pathogenesis of related diseases,as well as the potential value of migrasomes as diagnostic biomarkers or therapeutic targets,still require in-depth exploration and systematic elucidation.Therefore,this review aims to summarize the latest advances in migrasome research within disease contexts,provide a systematic overview of their roles in pathogenesis,and establish a theoretical foundation for their potential application as diagnostic biomarkers and therapeutic targets.
作者
陈智涵
王晨曦
蒋丽萍
CHEN Zhi-han;WANG Chen-xi;JIANG Li-ping(School of Pharmacy,Jiangxi Medical College,Nanchang University,Nanchang 330006,China;Jiangxi Provincial Key Laboratory of Drug Targets and New Drug Screening,Nanchang University,Nanchang 330006,China)
出处
《中国药理学通报》
北大核心
2026年第2期201-206,共6页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 82460719)。
关键词
迁移体
细胞外囊泡
信号传递
细胞间通讯
线粒体胞吐
收缩纤维
migrasomes
extracellular vesicles
signal transduction
intercellular communication
mitocytosis
retraction fibers
