摘要
【目的】探讨苍耳子鼻炎滴丸联合头孢呋辛治疗急性鼻窦炎患者的临床疗效。【方法】选取2023年3月至2025年3月本院收治的101例急性鼻窦炎患者,采用计算机生成的随机序列(由独立统计师完成)分为对照组(n=51,采用头孢呋辛+外观一致的安慰剂)和观察组(n=50,采用头孢呋辛+苍耳子鼻炎滴丸)。研究期间,对照组3例(失访2例、自行退出1例)和观察组2例(失访)脱落,最终96例完成全部随访(每组48例)。比较两组患者的临床疗效、炎症指标、鼻内镜评分(Lund-Kennedy评分)、临床症状以及不良反应发生情况。【结果】观察组患者总有效率高于对照组(P<0.05)。治疗后,观察组患者的血清超敏C反应蛋白(hs-CRP)及降钙素原(PCT)水平均低于对照组(P<0.05),Lund-Kennedy评分及鼻腔鼻窦结局测试-20(sinonasal outcome test-20,SNOT-20)各维度评分均低于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。【结论】苍耳子鼻炎滴丸联合头孢呋辛可提高急性鼻窦炎患者的临床疗效,减轻炎症反应,且安全性良好,值得临床推广应用。
【Objective】To explore the clinical efficacy of Xanthium Rhinitis Dripping Pills combined with cefuroxime in the treatment of patients with acute sinusitis.【Methods】A total of 101 patients with acute sinusitis admitted to our hospital from March 2023 to March 2025 were selected and divided into a control group(n=51,treated with cefuroxime plus placebo with identical appearance)and an observation group(n=50,treated with cefuroxime plus Xanthium Rhinitis Dripping Pills)using a computer-generated random sequence(completed by an independent statistician).During the study period,3 cases in the control group(2 lost to follow-up,1 withdrew voluntarily)and 2 cases in the observation group(lost to follow-up)dropped out,and finally 96 cases completed all follow-up visits(48 cases in each group).The clinical efficacy,inflammatory indicators,nasal endoscopy scores(Lund-Kennedy scores),clinical symptoms and incidence of adverse reactions were compared between the two groups.【Results】The total effective rate of the observation group was higher than that of the control group(P<0.05).After treatment,the serum levels of hypersensitive C-reactive protein(hs-CRP)and procalcitonin(PCT)in the observation group were lower than those in the control group(P<0.05),and the Lund-Kennedy scores and the scores of all dimensions of the Sinonasal Outcome Test-20(SNOT-20)in the observation group were lower than those in the control group(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).【Conclusion】Xanthium Rhinitis Dripping Pills combined with cefuroxime can improve the clinical efficacy of patients with acute sinusitis,alleviate the inflammatory response,and has good safety,which is worthy of clinical promotion and application.
作者
邵红
SHAO Hong(Department of Pharmacy,the Fifth Clinical College of Henan University of Chinese Medicine(Zhengzhou People's Hospital),Zhengzhou Henan 450000)
出处
《医学临床研究》
2026年第1期110-113,共4页
Journal of Clinical Research
关键词
鼻窦炎
急性病
滴丸
头孢呋辛
治疗结果
Sinusitis
Acute Disease
Dripping Pills
Cefuroxime
Treatment Outcome
