摘要
通过伪三元相图筛选艾叶挥发油微乳处方,以微乳原液油相含量、乳化剂与助乳化剂比值(K_(m))为考察因素,以微乳平均粒径和多分散系数(PDI)为评价指标,采用响应面法优化制备处方。最优处方条件为微乳原液油相含量22.07%,K_(m)值为2.63,乳化剂吐温80占比为56.45%,助乳化剂无水乙醇占比为21.47%,在此条件下制备的艾叶挥发油微乳平均粒径为11.20 nm,PDI为0.148,与预测值相比,偏差分别1.2%和3.3%,表明所制微乳粒径小,分散均匀且稳定性良好。
The microemulsion formulation of Artemisia argyi oil was screened using a pseudo-ternary phase diagram,with the oil phase content of the original microemulsion and the ratio of emulsifier to co-emulsifier as evaluation factors,and the average particle size and polydispersity index(PDI)of the microemulsion as assessment indicators.The response surface method was used to optimize the preparation formula.The optimal conditions were an oil phase content of 22.07%in the original microemulsion,a K_(m) value of 2.63,a Tween 80 proportion of 56.45%,and an anhydrous ethanol proportion of 21.47%.Under these conditions,the average particle size of the Artemisia argyi oil microemulsion was 11.20 nm,and the PDI was 0.148.Compared to the predicted values,the deviations were 1.2%and 3.3%,respectively.The microemulsion has a small particle size and good dispersion stability.
作者
龙伟
农秋冬
王威
王振涛
韦啟球
LONG Wei;NONG Qiudong;WANG Wei;WANG Zhentao;WEI Qiqiu(Changde Vocational Technical College,Changde 415000,China;Guangxi University of Science and Technology,Liuzhou 545000,China)
出处
《山东化工》
2026年第1期41-45,51,共6页
Shandong Chemical Industry
基金
常德市科技创新指导性项目(项目编号2023ZD17)
常德职业技术学院院级科研项目(项目编号ZY2407)。
关键词
艾叶油
微乳
伪三元相图
响应面法
处方优化
Artemisia argyi oil
microemulsion
pseudo-ternary phase diagram
response surface methodology
prescription optimization
