摘要
卵巢颗粒细胞(GCs)是影响卵泡发育的重要“中介”,在维持卵母细胞生长、激素分泌和卵巢微环境稳态中发挥关键作用。铁死亡是一种以铁依赖性脂质过氧化为特征的新型程序性细胞死亡方式,在GCs损伤及卵巢衰老过程中发挥重要作用。GCs铁死亡可造成卵泡发育不良,进而降低卵母细胞质量,最终导致卵巢储备功能减退(DOR)。研究表明,铁代谢失衡、脂质过氧化异常、抗氧化防御系统失常及非编码RNA调控紊乱均可通过诱导GCs铁死亡,加速DOR的发生发展。因此,通过调控GCs的铁代谢、脂质代谢及抗氧化系统,抑制铁死亡,可能成为延缓或逆转DOR的有效干预策略。这为进一步探索DOR的分子机制提供了理论依据,也为开发具有针对性的干预策略和新型疗法提供了潜在方向。
Ovarian granulosa cells(GCs)are important“mediators”that influence follicular development and play a crucial role in maintaining oocyte growth,hormone secretion,and the homeostasis of the ovarian microenvironment.Fer⁃roptosis is a novel form of programmed cell death characterized by iron⁃dependent lipid peroxidation,and it plays an impor⁃tant role in GC injury and ovarian aging.Ferroptosis of GCs can lead to poor follicular development,thereby reducing oo⁃cyte quality and ultimately causing diminished ovarian reserve(DOR).Studies have shown that iron metabolism imbal⁃ance,abnormal lipid peroxidation,dysfunction of the antioxidant defense system,and dysregulation of non⁃coding RNA(ncRNA)can all induce GC ferroptosis and accelerate the development and progression of DOR.Therefore,inhibiting fer⁃roptosis by regulating iron metabolism,lipid metabolism,and the antioxidant system in GCs may serve as an effective inter⁃vention strategy to delay or reverse DOR.This provides a theoretical basis for further exploring the molecular mechanisms of DOR and offers potential directions for developing targeted interventions and novel therapeutic approaches.
作者
张孝麒
毕富玺
ZHANG Xiaoqi;BI Fuxi(Gynecology Department,First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300381,China;不详)
出处
《山东医药》
2026年第1期151-154,共4页
Shandong Medical Journal
基金
天津市教委科研计划项目一般项目(2024KJ039)。
关键词
卵巢颗粒细胞
铁死亡
卵巢储备功能减退
ovarian granulosa cells
ferroptosis
diminished ovarian reserve
