摘要
目的评估利培酮联合认知行为疗法对比联合常规支持性心理治疗对精神分裂症患者疾病症状和社会功能水平等方面的作用效果差异。方法选取2024年2月至2025年2月洛阳市第五人民医院收治的120例精神分裂症患者,通过随机数表法分为对照组(利培酮联合常规支持性心理治疗)和研究组(利培酮联合认知行为疗法),每组60例。治疗周期16周,治疗前后通过简明精神病量表(BPRS)、阳性和阴性症状量表(PANSS)及住院精神患者社会功能评定量表(SSPI)评估症状控制和社会功能的变化,统计治疗期间两组患者不良反应发生率差异。结果研究组治疗有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组BPRS、PANSS评分均较治疗前降低,且研究组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组SSPI各项评分均较治疗前升高,且研究组高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论利培酮联合认知行为疗法能够显著提高精神分裂症患者的临床疗效,尤其在症状控制和提升社会功能方面表现理想。
Objective To evaluate the differences in the effects of risperidone combined with cognitive behavioral therapy(CBT)versus risperidone combined with routine supportive psychotherapy on symptom severity and social functioning in patients with schizophrenia.Methods A total of 120 patients with schizophrenia admitted to Luoyang Fifth People’s Hospital from February 2024 to February 2025 were enrolled and randomly assigned using a random number table to a control group(risperidone plus routine supportive psychotherapy)or a study group(risperidone plus CBT).with 60 patients in each group.The treatment duration was 16 weeks.Before and after treatment.changes in symptom control and social functioning were assessed using the Brief Psychiatric Rating Scale(BPRS).the Positive and Negative Syndrome Scale(PANSS).and the Social Function Scale for Inpatients(SSPI).The incidence of adverse reactions during treatment was compared between the two groups.Results The study group achieved a higher overall response rate than the control group.and the difference was statistically significant(P<0.05).After treatment.BPRS and PANSS scores decreased in both groups compared with baseline.and both scores were lower in the study group than in the control group.with statistically significant differences(P<0.05).After treatment.all SSPI domain scores increased in both groups compared with baseline.and the study group had higher SSPI scores than the control group.with statistically significant differences(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Risperidone combined with CBT can significantly improve clinical efficacy in patients with schizophrenia.particularly by enhancing symptom control and improving social functioning.
作者
周振华
王健
彭艳娜
寇香苹
ZHOU Zhenhua;WANG Jian;PENG Yanna;KOU Xiangping(Department of Psychiatry 19,Luoyang Fifth People’s Hospital,Luoyang Henan 471000,China)
出处
《临床研究》
2026年第2期32-35,共4页
Clinical Research
关键词
精神分裂症
认知行为疗法
利培酮
支持性心理治疗
schizophrenia
cognitive behavioral therapy
risperidone
supportive psychotherapy
