摘要
目的:分析银丹心脑通软胶囊联合阿替普酶(rt-PA)静脉溶栓治疗急性脑梗死(ACI)患者的临床疗效及对神经功能、氧化应激、血管功能、日常生活能力的影响。方法:选择2023年1月至2024年6月荥阳市人民医院收治的96例ACI患者,按照随机数字表法分为静脉溶栓组和中药联合组,每组48例。静脉溶栓组采用rt-PA静脉溶栓治疗,中药联合组采用银丹心脑通软胶囊联合rt-PA静脉溶栓治疗。治疗2周后,比较两组临床疗效、治疗前后神经功能缺损(NIHSS)评分、日常生活能力Barthel指数、氧化应激指标[血清丙二醛(MDA)、晚期氧化蛋白产物(AOPP)、过氧化物歧化酶(SOD)]、血管生成相关因子[血清转化生长因子-β1(TGF-β1)、血小板反应蛋白1(TSP1)、血管内皮生长因子(VEGF)]以及安全性。结果:治疗2周后,中药联合组临床总有效率为91.67%,高于静脉溶栓组的77.08%,差异有统计学意义(P<0.05)。治疗2周后,两组NIHSS评分和血清MDA,AOPP,TSP1水平低于治疗前,且中药联合组低于静脉溶栓组,差异有统计学意义(P<0.05)。治疗2周后,两组Barthel指数和SOD,TGF-β1,VEGF水平高于治疗前,且中药联合组高于静脉溶栓组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:银丹心脑通软胶囊联合rt-PA静脉溶栓治疗ACI患者具有更好的临床疗效,更有助于改善血管功能,抑制氧化应激反应,改善患者预后,且用药安全性高。
Objective:To analyze the clinical efficacy of yindan xinnaotong soft capsule combined with intravenous thrombolysis with Artipase(rt-PA)in the treatment of acute cerebral infarction(ACI)and its influence on neurological function,oxidative stress,vascular function and daily living ability.Methods:A total of 96 patients with ACI in xingyang people's hospital from January 2023 to June 2024 were prospectively selected and randomly divided into intravenous thrombolysis group and traditional Chinese medicine(TCM)combination group by random number table method,48 patients in each group.The intravenous thrombolysis group was treated with rt-PA intravenous thrombolysis,while the TCM combination group was treated with yindan xinnaotong soft capsules combined with rt-PA intravenous thrombolysis.After 2 weeks of treatment,the efficacy,neurological impairment(NIHSS)score,daily living ability Barthel index,oxidative stress indicators[malondialdehyde(MDA),advanced oxidation protein products(AOPP),superoxide dismutase(SOD)],angiogenesis-related factors[transforming growth factor-β1(TGF-β1),thrombopoietin 1(TSP1),vascular endothelial growth factor(VEGF)]before and after treatment,and safety were compared between two groups.Results:After 2 weeks of treatment,the total clinical effective rate in the TCM combination group was 91.67%,which was higher than that in the intravenous thrombolysis group(77.08%),there was significient difference(P<0.05).After 2 weeks of treatment,the NIHSS score and the serum levels of MDA,AOPP and TSP1 in the two groups were lower than those before treatment,and those in the important combination group were lower than those in the intravenous thrombolysis group,with statistical significance(P<0.05).After 2 weeks of treatment,the Barthel index and the levels of SOD,TGF-β1 and VEGF in the two groups were higher than those before treatment,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Yindan xinnaotong soft capsules combined with rt-PA intravenous thrombolysis in the treatment of ACI patients has better clincal effect,which can improve vascular function,inhibit oxidative stress response,improve patient prognosis,and is highly safe.
作者
马沛沛
陈瑞芳
李玮
MA Peipei;CHEN Ruifang;LI Wei(Xingyang People's Hospital,Xingyang 450100,China;Zhengzhou Central Hospital,Zhengzhou 450000,China;Henan Provincial People's Hospital,Zhengzhou 450000,China)
出处
《临床医药实践》
2026年第2期89-94,共6页
Proceeding of Clinical Medicine
关键词
急性脑梗死
银丹心脑通软胶囊
阿替普酶
氧化应激
血管生成相关因子
acute cerebral infarction
yindan xinnaotong soft capsules
alteplase
oxidative stress
angiogenesis-related factors
