摘要
背景:多种慢性肝病迁延不愈均会进入肝纤维化阶段,如未及时得到治疗则最终会进展为肝癌,严重影响患者的生命安全。但目前尚无治疗肝纤维化的特效药,最新研究表明间充质干细胞疗法较传统治疗方案具有显著优势,为肝纤维化治疗提供了新方向。目的:综述间充质干细胞及其衍生物治疗肝纤维化的作用机制。方法:以“间充质干细胞,间充质基质细胞,肝纤维化,肝细胞死亡,肝细胞样细胞,免疫调节,巨噬细胞,肝星状细胞,临床试验,临床研究”和“mesenchymal stem cells,mesenchymal stromal cells,MSCs,liver fibrosis,hepatic fibrosis,hepatocyte death,liver cell death,hepatocyte-like cells,immunomodulation,macrophage,hepatic stellate cells,clinical trials,clinical studies”分别作为中、英文关键词,在中国知网、PubMed数据库进行检索,最终纳入符合标准的81篇文献进行综述。结果与结论:通过对现有的研究进行总结,归纳间充质干细胞及其衍生物能够发挥抗纤维化作用并延缓疾病进展的作用机制,具体机制包括减少肝细胞死亡、分化为肝细胞样细胞、调控免疫反应、抑制肝星状细胞活化等,证实间充质干细胞及其衍生物可作为肝纤维化相关疾病治疗研究的新方向。
BACKGROUND:Multiple chronic liver diseases that fail to heal will progress to the stage of liver fibrosis.If not treated in a timely manner,they will eventually develop into liver cancer,severely threatening the safety of patients’lives.However,there is currently no specific drug for the treatment of liver fibrosis.Recent studies have demonstrated that mesenchymal stem cell therapy has significant advantages over traditional treatment protocols,providing a new direction for the treatment of liver fibrosis.OBJECTIVE:To review the mechanisms of action of mesenchymal stem cells and their derivatives in the treatment of liver fibrosis.METHODS:The Chinese and English keywords“mesenchymal stem cells,mesenchymal stromal cells,MSCs,liver fibrosis,hepatic fibrosis,hepatocyte death,liver cell death,hepatocyte-like cells,immunomodulation,macrophage,hepatic stellate cells,clinical trials,clinical studies”were used and searched in CNKI and PubMed databases,a total of 81 eligible articles were selected for this review.RESULTS AND CONCLUSION:Through summarizing existing studies,the mechanisms by which mesenchymal stem cells and their derivatives exert anti-fibrotic effects and delay disease progression have been identified.These specific mechanisms include reducing hepatocyte death,differentiating into hepatocyte-like cells,regulating immune responses,and inhibiting the activation of hepatic stellate cells.These findings confirm that mesenchymal stem cells and their derivatives can serve as a new research direction for the treatment of liver fibrosis-related diseases.
作者
樊龙雨
袁潇
谢亚楠
殷晓轩
Fan Longyu;Yuan Xiao;Xie Yanan;Yin Xiaoxuan(Shandong University of Traditional Chinese Medicine,Jinan 250355,Shandong Province,China;Yankuang New Journey General Hospital,Jining 273599,Shandong Province,China)
出处
《中国组织工程研究》
北大核心
2026年第19期4990-4999,共10页
Chinese Journal of Tissue Engineering Research
基金
山东省中医药科技项目(2020Z41),项目负责人:殷晓轩。
关键词
间充质干细胞
衍生物
肝纤维化
肝星状细胞
铁死亡
机制
mesenchymal stem cell
derivative
liver fibrosis
hepatic stellate cell
ferroptosis
mechanism
