摘要
新生儿缺氧缺血性脑病(hypoxic ischemic encephalopathy,HIE)是导致新生儿死亡和神经功能障碍的主要原因。现有疗法如亚低温治疗存在局限性和风险,亟需探索新的干预策略。自噬作为细胞适应性机制,通过清除受损细胞器和维持稳态在神经保护中发挥双重作用,从而在神经系统疾病中展现出潜在的治疗作用。该文综述了自噬关键调控通路、自噬调控药物及其在HIE治疗中的潜在应用,为HIE的治疗提供新的方向。
Hypoxic ischemic encephalopathy(HIE)is a major cause of neonatal death and neurological dysfunction.Existing therapies such as hypothermia treatment have limitations and risks,and new intervention strategies are urgently needed.As a cellular adaptive mechanism,autophagy plays a dual role in neuroprotection by removing damaged organelles and maintaining homeostasis,and has shown potential therapeutic effects in neurological diseases.This article reviews the key regulatory pathways,autophagy regulatory drugs and their potential applications in the treatment of HIE,so as to provide new directions for the treatment of HIE.
作者
钟亚婧
张超
印彩丽
阴怀清
阴崇娟
Zhong Yajing;Zhang Chao;Yin Caili;Yin Huaiqing;Yin Chongjuan(First Clinical Medical College,Shanxi Medical University,Taiyuan 030000,China;Department of Neonatology,First Hospital of Shanxi Medical University,Taiyuan 030000,China)
出处
《国际儿科学杂志》
2025年第12期817-820,共4页
International Journal of Pediatrics
基金
山西省科学技术厅青年科学研究项目(20210302124650)。
关键词
婴儿
新生
缺氧缺血性脑病
自噬
褪黑素
干细胞疗法
神经保护
Infant,newborn
Hypoxic ischemic encephalopathy
Autophagy
Melatonin
Stem cells
Neuroprotection
