摘要
心血管疾病是全球范围内致死率最高的一类疾病,其致病机制和功能修复仍有待阐明。人类诱导多能干细胞(hiPSC)的出现和发展,为心血管疾病研究提供了新的契机,极大地加深了人类对于心血管疾病的认识。本文总结了hiPSC来源的心血管细胞和心脏类器官的最新研究进展并介绍本团队在该领域的相关研究成果,重点讨论了hiPSC来源心肌细胞和非心肌细胞的诱导分化,及其在疾病建模、功能修复、药物筛选及机制解析中的作用。此外,本文还简要概述了hiPSC来源心脏类器官在心脏疾病研究中的应用现状。
Cardiovascular diseases are the leading cause of mortality worldwide,yet their pathogenic mechanisms and functional repair remain incompletely understood.The emergence and development of human induced pluripotent stem cells(hiPSC)have provided unprecedented opportunities for cardiovascular disease research,and markedly enhanced our understanding of cardiovascular disease mechanisms.This review summarizes recent advances in cardiovascular cells and cardiac organoids derived from hiPSC,and presents our team's related research findings in this field.It highlights the induction and differentiation of hiPSC-derived cardiomyocytes and non-myocytes,as well as their roles in disease modeling,functional repair,drug screening,and mechanistic investigation.Furthermore,the current applications of hiPSC-derived cardiac organoids in cardiovascular disease research are also discussed.
作者
黄亮
向秋玲
HUANG Liang;XIANG Qiuling(Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou 510080,China)
出处
《中山大学学报(医学科学版)》
北大核心
2026年第1期43-54,共12页
Journal of Sun Yat-Sen University:Medical Sciences
基金
国家重点研发计划项目(2024YFE0217400)
国家自然科学基金(82470367,82272164)
广东省自然科学基金(2024A1515013135)。
关键词
人诱导多能干细胞
心血管疾病
心肌细胞
非心肌细胞
心脏类器官
human induced pluripotent stem cell
cardiovascular diseases
cardiomyocytes
non-myocytes
cardiac organoids
