摘要
心血管疾病已成为我国城市和农村人群最主要的死亡原因。近年研究发现,线粒体功能障碍包括线粒体动力学失衡、自噬失调、线粒体膜去极化和线粒体通透性转换孔(mPTP)开放、细胞凋亡、活性氧产生过量、ATP合成减少、钙离子紊乱等影响心血管细胞正常的生理功能,并促进动脉粥样硬化、高血压、缺血再灌注损伤、肥厚型心肌病、心律失常和心力衰竭等发生发展,进而引发各种心血管疾病。本文综述了线粒体功能障碍在心血管疾病中的作用,旨在为心血管疾病的研究和治疗提供新的思路。
Cardiovascular disease has become the leading cause of death in both urban and rural populations in China.Recent studies have found mitochondrial dysfunction,such as mitochondrial dynamics imbalance,dysregulation of autophagy,mitochondrial membrane depolarization and mPTP opening,apoptosis,excessive production of reactive oxygen species,reduction of ATP synthesis and calcium ion disorder,affect the normal physiological function of cardiovascular cells,and promote the occurrence and development of atherosclerosis,hypertension,ischemia-reperfusion injury,hypertrophic cardiomyopathy,arrhythmia,heart failure,etc.,thus leading to various cardiovascular diseases.This paper reviews the role of mitochondrial dysfunction in cardiovascular diseases and aims to provide new ideas for the research and treatment of cardiovascular diseases.
作者
郑惠娟
曹运长
张瑛
欧阳云
王五香
封少龙
ZHENG Huijuan;CAO Yunchang;ZHANG Ying;OAYANG Yun;WANG Wuxiang;FENGShaolong(The Institute of Preventive Medicine&Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health&School of Public Health,Guilin Medical University,Guilin,Guangxi 541199,China;The Library,University of South China,Hengyang,Hunan 421001,China;The State Key Laboratory of Organic Geochemistry&Guangzhou Institute of Geochemistry,Chinese Academy of Sciences,Guangzhou,Guangdong 510640,China)
出处
《中国动脉硬化杂志》
2026年第1期73-79,86,共8页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金项目(41877390)
有机地球化学国家重点实验室开放基金(SKLOG-202213)。
关键词
线粒体
线粒体功能障碍
心血管疾病
mitochondria
mitochondrial dysfunction
cardiovascular diseases
