摘要
目的 研究美托洛尔联合普罗帕酮治疗尘肺病并慢性肺源性心脏病(肺心病)引起快速心律失常的疗效。方法 选取80例尘肺病并慢性肺心病引起快速心律失常患者,以随机数字表法分为对照组(n=40,采用美托洛尔治疗)及观察组(n=40,在对照组基础上联合普罗帕酮治疗)。比较两组临床疗效、快速心律失常发作频率、快速心律失常持续时间、心功能指标及不良反应发生率。结果 治疗2周后,观察组治疗总有效率95.00%较对照组的80.00%更高(P<0.05)。治疗2周后,与对照组的(1.41±0.29)次/24 h、(7.21±0.64)min/次比较,观察组快速心律失常发作频率(1.17±0.34)次/24 h更低,快速心律失常持续时间(6.63±0.58)min/次更短(P<0.05)。治疗2周后,两组左心室射血分数(LVEF)、右心室射血分数(RVEF)均较本组治疗前升高,且观察组更高,肺动脉收缩压(PASP)均较本组治疗前降低,且观察组更低(P<0.05)。两组不良反应发生率接近(P>0.05)。结论 采用美托洛尔联合普罗帕酮治疗尘肺病并慢性肺心病引起快速心律失常的疗效较好,可降低快速心律失常发作频率,并减少持续时间,改善心功能,安全性较高。
Objective To study the efficacy of metoprolol combined with propafenone in the treatment of tachyarrhythmia caused by pneumoconiosis with chronic pulmonary heart disease.Methods 80 patients with tachyarrhythmia caused by pneumoconiosis with chronic pulmonary heart disease were selected,and were divided into control group(n=40,metoprolol treatment)and observation group(n=40,propafenone treatment on the basis of the control group)by means of random number table.The clinical efficacy,frequency of tachyarrhythmia,duration of tachyarrhythmia,cardiac function indicators and incidence of adverse reactions were compared between groups.Results After 2 weeks of treatment,the total effective rate of treatment 95.00%in the observation group was higher than the control group's 80.00%(P<0.05).Compared with the control group[(1.41±0.29)times/24 h and(7.21±0.64)min/time],the frequency of tachyarrhythmia(1.17±0.34)times/24 h was lower in the observation group,and the duration of tachyarrhythmia(6.63±0.58)min/time was shorter after 2 weeks of treatment(P<0.05).After 2 weeks of treatment,the left ventricular ejection fraction(LVEF)and right ventricular ejection fraction(RVEF)in both groups were increased compared to before treatment in this group,and the two indicators in the observation group were higher;the pulmonary artery systolic pressure(PASP)was reduced compared to before treatment in this group,and the indicator was lower in the observation group(P<0.05).The incidence of adverse reactions in the two groups was similar(P>0.05).Conclusion Metoprolol combined with propafenone has good efficacy in the treatment of tachyarrhythmia caused by pneumoconiosis with chronic pulmonary heart disease.It can reduce the frequency of tachyarrhythmia,shorten the duration of tachyarrhythmia and improve the cardiac function,and it has high safety.
作者
刘钊
刘桃英
LIU Zhao;LIU Tao-ying(Department of Internal Medicine,Xinyu Mining Hospital,Xinyu 338000,China)
出处
《中国现代药物应用》
2026年第5期1-4,共4页
Chinese Journal of Modern Drug Application
基金
新余市科技计划项目(项目编号:20233090978)。
