摘要
目的:观察五味饮加减佐治血热瘀结型急性血栓性浅静脉炎(SVT)的疗效。方法:选取2022年1月至2024年4月我院收治的152例急性SVT患者,按照随机数字表法分为西药组(予以常规治疗,n=76)和中西联合组(在西药组基础上联合五味饮加减治疗,n=76)。比较两组患者临床疗效,治疗前后中医症状积分、静脉临床严重程度评分(VCSS)、血液流变学指标(红细胞压积、纤维蛋白原、血浆黏度100 s、全血黏度200 s)、血清炎症因子水平[高敏-C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]及不良反应。结果:中西联合组治疗总有效率(97.37%)高于西药组(88.16%,P<0.05)。治疗后,两组中医症状积分评分、VCSS评分、红细胞压积、纤维蛋白原、血浆黏度100s、全血黏度200s、hs-CRP、IL-6、TNF-α水平较治疗前均下降(P<0.05),且治疗后,中西联合组患者上述指标水平降低幅度均大于西药组(P<0.05)。两组患者不良反应发生率差异无统计学意义(P>0.05)。结论:五味饮加减佐治血热瘀结型SVT患者,可有效缓解其临床症状,血液流变学指标,降低炎症因子水平,对控制SVT病情进展具有一定疗效。
Objective:To observe the efficacy of modified wuwei decoction adjuvant therapy on blood heat stasis accumulation type of acute superficial vein thrombophlebitis(SVT).Methods:152 patients with acute SVT admitted in our hospital from January 2022 to April 2024 were selected.According to the random number table method,these patients were divided into the western medicine group(routine treatment,n=76)and the combined Chinese-western medicine group(modified wuwei decoction on the basis of the western medicine group,n=76).The clinical efficacy,TCM symptoms scores,venous clinical severity score(VCSS),hemorheological indicators(hematocrit,fibrinogen,plasma viscosity 100s,whole blood viscosity 200s)and serum inflammatory factors levels[high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]before and after the treatment and the adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the combined Chinese-western medicine group(97.37%)was higher than that in the western medicine group(88.16%)(P<0.05).After treatment,the scores of TCM symptoms,the scores of VCSS,the levels of hematocrit,fibrinogen,plasma viscosity 100 s,whole blood viscosity 200 s,hs-CRP,IL-6 and TNF-αin both groups decreased compared with those before treatment(P<0.05),and the decrease of the above indicators in the combined Chinese-western medicine group was greater than that in the western medicine group(P<0.05).There were no statistically significant differences in the incidence rates of adverse reactions between the two groups of patients(P>0.05).Conclusion:Modified wuwei decoction can effectively relieve the clinical symptoms and hemorheological indicators and reduce the levels of inflammatory factors in patients with SVT of blood heat stasis accumulation type,and it has certain efficacy on controlling the progression of SVT.
作者
廖宇
孙冉冉
郭宇清
王晓鹏
肖阳春
高美丽
LIAO Yu;SUN Ranran;GUO Yuqing;WANG Xiaopeng;XIAO Yangchun;Gao Meili(Shunyi Hospital of Beijing Hospital of Traditional Chinese Medicine,Beijing 101300,China;China Academy of Chinese Medical Sciences Wangjing Hospital,Beijing 100102,China)
出处
《中国医药导刊》
2025年第11期1197-1202,共6页
Chinese Journal of Medicinal Guide
基金
中国中医科学院科技创新工程课题(CI2021A02903)。
关键词
急性血栓性或浅静脉炎
五味饮
血热瘀结型
炎症因子
血液流变学
Acute superficial vein thrombophlebitis
Wuwei decoction
Blood heat stasis accumulation type
Inflammatory factors
Hemorheology
