摘要
目的 探讨氢氯噻嗪联合厄贝沙坦方案治疗老年原发性高血压患者的临床疗效。方法 164例老年原发性高血压患者,随机分为研究组和对照组,每组82例。研究组给予氢氯噻嗪联合厄贝沙坦方案治疗,对照组给予氢氯噻嗪单药方案治疗。比较两组患者血压控制情况、血液生化指标变化情况、不良事件发生率。结果 治疗12周后,两组患者的收缩压、舒张压较本组治疗前明显下降,且研究组患者的收缩压(135.62±7.34)mm Hg(1 mm Hg=0.133 kPa)、舒张压(82.05±5.27)mm Hg低于对照组的(142.53±7.18)、(84.67±5.41)mm Hg(P<0.05)。研究组患者治疗12周后血压达标率为73.17%,高于对照组的54.88%(P<0.05)。治疗12周后,两组患者血清钠及对照组患者血清钾均较本组治疗前降低,对照组患者血清钠-钾比值较本组治疗前升高,且研究组患者血清钾高于对照组,血清钠、血清钠-钾比值低于对照组(P<0.05)。研究组患者心血管事件发生率3.66%、药物相关不良反应发生率6.10%较对照组的12.20%、15.85%显著更低(P<0.05)。结论 氢氯噻嗪联合厄贝沙坦方案在老年原发性高血压治疗中具有显著的降压效果,值得在临床上进一步推广应用。
Objective To explore the clinical efficacy of hydrochlorothiazide combined with irbesartan in the treatment of elderly patients with essential hypertension.Methods 164 elderly patients with essential hypertension were enrolled and randomly divided into study group and control group,82 cases in each group.The study group was treated with hydrochlorothiazide combined with irbesartan,and the control group was treated with hydrochlorothiazide alone.The blood pressure control,changes in blood biochemical indicators and the incidence of adverse events of the two groups of patients were compared.Results After 12 weeks of treatment,both groups showed significant reductions in systolic and diastolic blood pressure compared to baseline in this group.Moreover,the study group exhibited lower systolic blood pressure(135.62±7.34)mm Hg(1 mm Hg=0.133 kPa)and diastolic blood pressure(82.05±5.27)mm Hg compared to those in the control group[(142.53±7.18)and(84.67±5.41)mm Hg](P<0.05).The blood pressure control rate in the study group after 12 weeks of treatment was higher than that in the control group(73.17%vs.54.88%,P<0.05).After 12 weeks of treatment,the serum sodium levels decreased in both groups and serum potassium levels decreased in the control group compared to baseline in this group.Additionally,the serum sodium-to-potassium ratio increased in the control group compared to baseline in this group.Furthermore,patients in the study group had higher serum potassium levels than that in the control group,while serum sodium levels and the sodium-to-potassium ratio were lower than those in the control group(P<0.05).The incidence of cardiovascular events in the study group was 3.66%,and the incidence of drug-related adverse reactions was 6.10%,both significantly lower than those in the control group(12.20%and 15.85%)(P<0.05).Conclusion Hydrochlorothiazide combined with irbesartan has a significant antihypertensive effect in the treatment of elderly patients with essential hypertension,and is worthy of further clinical application.
作者
江帆
陈智元
JIANG Fan;CHEN Zhi-yuan(Fu'an Chengyang Health Center,Fu'an 355000,China)
出处
《中国现代药物应用》
2026年第4期7-11,共5页
Chinese Journal of Modern Drug Application
关键词
老年原发性高血压
氢氯噻嗪
厄贝沙坦
疗效
Essential hypertension in the elderly
Hydrochlorothiazide
Irbesartan
Efficacy
