摘要
目的:比较苯磺酸左氨氯地平片与硝苯地平控释片治疗高血压的效果。方法:将100例高血压患者纳入研究,均为2023年3月—2025年3月北京市东城区龙潭社区卫生服务中心收治,采用抽签法将患者随机分为参照组(50例,给予硝苯地平控释片治疗)和试验组(50例,给予苯磺酸左氨氯地平片治疗)。对比两组降压效果、血压指标、血压变异性及不良反应发生情况。结果:与参照组相比,试验组治疗效果更好(P=0.004)。与治疗前相比,两组治疗后的收缩压、舒张压降低,且试验组比参照组低(P<0.001)。治疗后,两组24 h收缩压标准差、24 h收缩压加权标准差、24 h收缩压平均实际变异性降低(P<0.05),且试验组比参照组低(P<0.001)。试验组恶心、面部潮红、踝关节轻度水肿总发生率低于参照组(P=0.027)。结论:与硝苯地平控释片相比,苯磺酸左氨氯地平片治疗高血压的效果更好,可控制血压水平,降低收缩压变异性,减少不良反应。
Objective:To compare the effects of levamlodipine besylate tablets and nifedipine controlled-release tablets in the treatment of hypertension.Methods:A total of 100 patients with hypertension were included in the study,all of whom were treated at Beijing Dongcheng District Longtan Community Health Service Center from March 2023 to March 2025.The patients were randomly divided by lottery into a control group(50 cases,treated with nifedipine controlled-release tablets)and an experimental group(50 cases,treated with lercanidipine besylate tablets).The antihypertensive effects,blood pressure indicators,blood pressure variability and the occurrence of adverse reactions of the two groups were compared.Results:Compared with the control group,the experimental group showed better treatment effects(P=0.004).Compared with before treatment,both groups had reductions in systolic and diastolic blood pressure after treatment,with the experimental group being lower than the control group(P<0.001).After treatment,the standard deviation of 24-hour systolic blood pressure,the weighted standard deviation of 24-hour systolic blood pressure,and the average actual variability of 24-hour systolic blood pressure in both groups decreased(P<0.05),and the experimental group was lower than the reference group(P<0.001).The total incidence of nausea,facial flushing,and mild ankle edema in the experimental group was lower than that in the reference group(P=0.027).Conclusion:Compared with nifedipine controlled-release tablets,levamlodipine besylate tablets have a better therapeutic effect on hypertension,can control blood pressure levels,reduce systolic blood pressure variability,and minimize adverse reactions.
作者
纪雯
Ji Wen(Beijing Dongcheng District Longtan Community Health Service Center,Beijing 100061,China)
出处
《中国社区医师》
2025年第32期40-42,共3页
Chinese Community Doctors
关键词
高血压
苯磺酸左氨氯地平片
硝苯地平控释片
血压变异性
不良反应
Hypertension
Levamlodipine besylate tablets
Nifedipine controlled-release tablets
Blood pressure variability
Adverse reactions
