摘要
目的:探讨^(125)I放射性粒子植入治疗盆腔恶性肿瘤的近期临床疗效及安全性。方法:回顾性分析2014年1月至2024年8月东南大学附属中大医院收治的盆腔恶性肿瘤患者121例,主要研究终点是肿瘤局部控制率,次要观察指标是疼痛缓解率及安全性。患者疼痛评分采用疼痛数字评价量表(NRS)评估,比较治疗前后疼痛评分、口服止疼药物日剂量,红细胞、白细胞、血小板计数等骨髓造血功能相关指标的变化。结果:术后1个月、2个月的疾病控制率分别为86.8%、90.9%,术后1周、1个月、2个月NRS评分分别为(7.1±1.6)、(6.8±1.9)、(6.6±1.5)分,较术前NRS评分[(7.6±1.8)分]改善,差异均有统计学意义(P<0.05);术后1个月、2个月吗啡缓释片日剂量分别为(22.4±3.9)mg、(21.7±3.4)mg,较术前(23.5±4.8)mg下降,差异均有统计学意义(P<0.05);红细胞、白细胞、血小板、单核细胞计数较术前,差异均无统计学意义(P>0.05),淋巴细胞计数较术前升高,差异有统计学意义(P<0.05);术后不良反应中1级不良反应率6.6%(8/121),3级不良反应率0.8%(1/121)。结论:^(125)I放射性粒子植入治疗盆腔恶性肿瘤可有效控制局部肿瘤生长,缓解患者疼痛症状,近期安全可耐受。
Objective:To investigate the short-term efficacy and safety of ^(125)I radioactive seed implantation in the treatment of pelvic malignancies.Methods:A total of 121 patients with pelvic malignancies admitted to Zhongda Hospital,Southeast University from January 2014 to August 2024 were retrospectively enrolled.The primary endpoint was the local tumor control rate,and the secondary endpoints included pain relief rate and safety.Pain scores were assessed using the numeric rating scale(NRS).Pain scores,daily doses of oral pain medication,and indicators of bone marrow function(including red-blood-cell,white-blood-cell and platelet counts)were compared before and after treatment.Results:The disease control rates at 1 month and 2 months after surgery were 86.8%and 90.9%,respectively.The NRS scores at 1 week,1 month,and 2 months after surgery were(7.1±1.6),(6.8±1.9),and(6.6±1.5),respectively;all were significantly lower than the preoperative value(7.6±1.8,P<0.05).The daily doses of morphine sustained-release tablets were(22.4±3.9)mg and(21.7±3.4)mg at 1 and 2 months after surgery,respectively,significantly lower than the preoperative dose of(23.5±4.8)mg(P<0.05).There were no significant differences in red-blood-cell,white-blood-cell,platelet,or monocyte counts compared with the preoperative levels(P>0.05),while the lymphocyte count was significantly higher than the preoperative value(P<0.05).Postoperative adverse reactions were grade 1 in 6.6%(8/121)of patients and grade 3 in 0.8%(1/121).Conclusion:^(125)I radioactive seed implantation can effectively control local tumor growth and relieve pain in patients with pelvic malignancies.It is well tolerated and safe in the short term.
作者
杜鲲
王勇
郭金和
朱光宇
DU Kun;WANG Yong;GUO Jinhe;ZHU Guangyu(Department of Interventional Radiology,Xinyang Municipal Central Hospital,Xinyang 464000,China;Department of Interventional Radiology and Vascular Surgery,Zhongda Hospital,Medical School,Southeast University,Nanjing 210009,China)
出处
《现代医学》
2025年第11期1757-1762,共6页
Modern Medical Journal
