摘要
目的探讨血清学实验室指标与创伤性骨折患者术后深静脉血栓(deep vein thrombosis,DVT)发生风险的关系。方法抽样选取2022年1月至2023年12月在台州博爱医院接受手术治疗创伤性骨折患者共104例,根据术后1个月内有无DVT发生分为DVT组(39例)和无DVT组(65例);采用单因素及多因素Logistics回归模型筛选患者术后DVT发生风险独立影响因素,并进一步采用Pearson检验评估血清学实验室指标与术后DVT发生风险间相关性。结果两组全身麻醉比例、术中输血比例、凝血酶时间、纤维蛋白原、D-二聚体及血小板计数水平比较差异有统计学意义(P<0.05)。以术后DVT是否发生作为因变量,两组间比较单因素分析有统计学意义指标作为自变量纳入Logistics回归模型进行多因素分析,结果显示凝血酶时间(B=0.91,SE=0.49,Waldχ^(2)=7.16,OR=1.35,95%CI:1.10~3.57)、纤维蛋白原(B=2.07,SE=0.70,Waldχ^(2)=12.17,OR=9.56,95%CI:2.34~22.30)及D-二聚体水平(B=3.50,SE=0.89,Waldχ^(2)=22.31,OR=27.68,95%CI:5.07~41.81)均是创伤性骨折患者术后DVT发生风险独立影响因素(P分别为0.042,0.009,<0.001)。Pearson检验分析结果显示,凝血酶时间、纤维蛋白原及D-二聚体水平均与创伤性骨折患者术后DVT发生风险呈正相关(P<0.05)。结论创伤性骨折患者随术前凝血酶时间、纤维蛋白原及D-二聚体水平增加则术后DVT发生风险显著升高。
Objective To explore the relationship between serological laboratory indicators and the risk of postoperative deep vein thrombosis(DVT)in patients with traumatic fractures.Methods A total of 104 patients with traumatic fractures who underwent surgical treatment in our hospital from January 2022 to December 2023 were selected.They were divided into a DVT group(39 cases)and a non-DVT group(65 cases)based on the presence or absence of DVT within one month postoperatively.Univariate and multivariate logistic regression models were used to screen independent risk factors for postoperative DVT,and Pearson tests were further employed to assess the correlation between serological laboratory indicators and postoperative DVT risk.Results Significant differences were observed between the two groups in the proportions of general anesthesia,intraoperative blood transfusion,prothrombin time,fibrinogen,D-dimer,and platelet count levels(P<0.05).Using postoperative DVT occurrence as the dependent variable,statistically significant indicators from univariate analysis were included in the logistic regression model for multivariate analysis.The results showed that prothrombin time(B=0.91,SE=0.49,Waldχ^(2)=7.16,OR=1.35,95%CI:1.10~3.57),fibrinogen(B=2.07,SE=0.70,Waldχ^(2)=12.17,OR=9.56,95%CI:2.34~22.30),and D-dimer levels(B=3.50,SE=0.89,Waldχ^(2)=22.31,OR=27.68,95%CI:5.07~41.81)were independent risk factors for postoperative DVT in patients with traumatic fractures(P=0.042,0.009,and<0.001,respectively).Pearson test analysis revealed that prothrombin time,fibrinogen,and D-dimer levels were positively correlated with the risk of postoperative DVT in patients with traumatic fractures(P<0.05).Conclusion The risk of postoperative DVT in patients with traumatic fractures significantly increases with elevated preoperative levels of prothrombin time,fibrinogen,and D-dimer.
作者
胡玲贇
陈权勇
周志米
HU Lingyun;CHEN quanyong;ZHOU Zhimi(Taizhou Boai Hospital,Zhejiang 318050,China)
出处
《浙江创伤外科》
2025年第12期2226-2229,共4页
Zhejiang Journal of Traumatic Surgery
关键词
血清学
实验室指标
创伤性骨折
手术
深静脉血栓
Serology
Laboratory indicators
Traumatic fracture
Surgery
Deep vein thrombosis
