摘要
目的探讨儿童反复呼吸道感染(RRTI)间歇期不同给药方案的价值。方法将2020年8月至2022年1月收治的儿童RRTI间歇期183例按照电脑随机数字表法分为3组,各61例。3组均给予常规治疗,在此基础上,对照1组给予小儿豉翘清热颗粒,对照2组给予维生素AD,联合组给予小儿豉翘清热颗粒联合维生素AD。比较3组炎症状态[C反应蛋白(CRP)、白细胞介素-6(IL-6)、Toll受体4(TLR4)]、体液免疫[IgA、IgM、IgG]、不良反应及治疗后6个月呼吸道感染的再发率。结果联合组治疗7 d、1个月后CRP、IL-6、TLR4低于对照1组和对照2组,且对照1组低于对照2组(P<0.05);联合组治疗7 d、1个月后IgA、IgM、IgG高于对照1组和对照2组,且对照2组高于对照1组(P<0.05);治疗期间、治疗后6个月,联合组呼吸道感染再发率低于对照1组和对照2组(P<0.05);对照1组、对照2组、联合组不良反应发生率[0(0/61)、1.64%(1/61)、3.28%(2/61)]比较差异无统计学意义(P>0.05)。结论小儿豉翘清热颗粒抗炎作用显著,维生素AD在改善体液免疫功能方面具有优势,二者联合用于儿童RRTI间歇期,可协同改善炎症状态和体液免疫,安全可靠,并能减少呼吸道感染的发生。
Objective To investigate the value of different dosing regimens during the remission phase of recurrent respiratory tract infection(RRTI)in children.Methods A total of 183 children during the remission phase of RRTI from August 2020 to January 2022 were divided into three groups according to the computer random number table method,with 61 patients in each group.The three groups were given conventional treatment.On this basis,the control group 1 was given Xiao'er Chiqiao Qingre granules,the control group 2 was given vitamin AD,and the combination group was given Xiao'er Chiqiao Qingre granules combined with vitamin AD.The inflammatory status[C-reactive protein(CRP),interleukin-6(IL-6),Toll receptor 4(TLR4)],humoral immunity[IgA,IgM,IgG],adverse reactions and recurrence rate of respiratory tract infection at 6 months after treatment were compared among the three groups.Results At 7 d and 1 month after treatment,CRP,IL-6 and TLR4 in the combination group were lower than those in the control group 1 and the control group 2,and lower in the control group 1 than in the control group 2(P<0.05).At 7 d and 1 month after treatment,IgA,IgM and IgG in the combination group were higher than those in the control group 1 and the control group 2,which were higher in the control group 2 than in the control group 1(P<0.05).During treatment and at 6 months after treatment,the recurrence rate of respiratory tract infection in the combination group was lower than that in the control group 1 and the control group 2(P<0.05).There was no significant difference in the incidence of adverse reactions among the control group 1,the control group 2 and the combination group[0(0/61),1.64%(1/61),3.28%(2/61)](P>0.05).Conclusion Xiao'er Chiqiao Qingre granules has a significant anti-inflammatory effect,and vitamin AD has advantages in improving humoral immune function.The combination of the two in the interval period of RRTI in children can synergistically improve the inflammatory state and humoral immunity,which is safe and reliable,and can reduce the incidence of respiratory tract infection.
作者
周锋
贾会杰
ZHOU Feng;JIA Huijie(Department of pediatrics,Pukou District Hospital of Traditional Chinese Medicine,Nanjing 211800,China)
出处
《临床误诊误治》
2025年第24期116-121,共6页
Clinical Misdiagnosis & Mistherapy
基金
江苏省妇幼健康科研项目(F202122)。
关键词
小儿豉翘清热颗粒
维生素AD
儿童反复呼吸道感染
C反应蛋白
白细胞介素-6
体液免疫
Xiao'er Chiqiao Qingre granules
vitamin AD
recurrent respiratory tract infection in children
C-reactive protein
interleukin-6
humoral immunity
