摘要
目的:探讨根治性鼻内镜手术对嗜酸性粒细胞型慢性鼻窦炎伴鼻息肉(EosCRSwNP)患者Lund-Kennedy评分、复发情况等的影响。方法:回顾性选取孝感市第一人民医院收治的EosCRSwNP患者88例,选取时间为2021年2月—2023年5月。依据手术方法的不同,将患者分为对照组(n=45,采用功能性鼻内镜手术)、观察组(n=43,采用根治性鼻内镜手术)。比较两组病情控制情况、VAS评分、Lund-Kennedy评分、SF-36评分、炎症因子水平、并发症及复发情况。结果:观察组术后6个月总控制率较对照组高(P<0.05);观察组术后1年VAS评分、Lund-Kennedy评分较对照组低,SF-36评分较对照组高(P<0.05);观察组术后6个月IL-1β、鳞状细胞癌抗原(SCCA)水平较对照组低,IL-35水平较对照组高(P<0.05);两组并发症发生率比较,差异无统计学意义(P>0.05);观察组术后1年复发率较对照组低(P<0.05)。结论:根治性鼻内镜手术治疗EosCRSwNP安全有效,可有效控制病情,减轻炎症反应程度,降低复发风险,安全性高,并可提高生活质量。
Objective:To investigate the effects of radical nasal endoscopic surgery on Lund-Kennedy score and recurrence of patients with eosinophilic chronic sinusitis with nasal polyps(EosCRSwNP).Method:Eightyeight patients with EosCRSwNP admitted to Xiaogan First People's Hospital were retrospectively enrolled,with the enrollment period from February 2021 to May 2023.According to the different surgical methods,the patients were divided into a control group(n=45,treated with functional nasal endoscopic surgery)and an observation group(n=43,treated with radical nasal endoscopic surgery).The disease control status,VAS scores,Lund-Kennedy score,SF-36 scores,inflammatory factor levels,complications,and recurrence were compared between the two groups.Result:The total control rate of the observation group at six months after surgery was higher than that of the control group(P<0.05).One year after surgery,the VAS scores and Lund-Kennedy scores of the observation group were lower than those of the control group,and the SF-36 scores was higher than that of the control group(P<0.05).Six months after surgery,the levels of IL-1βand squamous cell carcinoma antigen(SCCA)in the observation group were lower than those in the control group,and the levels of IL-35 was higher than that in the control group(P<0.05).There was no statistically significant difference in the incidence of complications between the two groups(P>0.05).The recurrence rate of the observation group one year after surgery was lower than that of the control group(P<0.05).Conclusion:Radical endoscopic nasal surgery for EosCRSwNP is safe and effective,which can effectively control the condition,reduce the degree of inflammatory response,lower the risk of recurrence,has high safety,and can improve the quality of life.
作者
张乔
ZHANG Qiao(Department of Otorhinolaryngology,Xiaogan First People's Hospital,Xiaogan 432000,China)
出处
《中国医学创新》
2025年第36期124-128,共5页
Medical Innovation of China
