摘要
由外伤、感染、糖尿病等原因导致的伤口或皮肤缺损逐年增多,给全球医疗保健系统造成了极大的负担。金属有机框架材料(MOFs)是由金属离子或金属簇和有机配体通过配位键所形成的纳米材料,具有孔隙率高、比表面积大、结构可调和生物相容性好等优点。MOFs可以通过降解释放金属离子来调节细胞行为和杀灭细菌。此外,MOFs还可以作为载体递送生物活性成分发挥抗炎、抗氧化和促细胞生成作用。本文通过系统梳理国内外相关文献,总结了各类MOFs在皮肤修复领域的合成方法、分类与应用策略,并在此基础上归纳了该领域当前面临的挑战,对其未来发展趋势进行了展望。
The incidence of wounds or skin defects caused by trauma,infection,diabetes,and other factors has been increasing year by year,imposing a substantial burden on global healthcare systems.Metal-organic frameworks(MOFs)are nanomaterials formed by metal ions or metal clusters and organic ligands through coordination bonds,featuring high porosity,large specific surface area,tunable structure,and excellent biocompatibility.MOFs can regulate cellular behaviors and kill bacteria by releasing metal ions during degradation.Additionally,MOFs can act as carriers for delivering bioactive components to exert anti-inflammatory,antioxidant,and cell proliferation-promoting effects.By systematically reviewing relevant domestic and international literature,this paper summarized the synthesis methods,classification,and application strategies of various MOFs in the field of skin repair.On this basis,it also concluded the current challenges in this field and provided an outlook on its future development trends.
作者
马珊珊
吴雯婷
刘豪
刘明(综述)
邢飞(审校)
MA Shanshan;WU Wenting;LIU Hao;LIU Ming;XING Fei(Department of Laboratory Medicine,West China Hospital,Sichuan University,Chengdu 610041,P.R.China;West China School of Medicine,Sichuan University,Chengdu 610041,P.R.China;Department of Orthopedics,West China Hospital,Sichuan University,Chengdu 610041,P.R.China;Department of Pediatric Surgery,West China Hospital,Sichuan University,Chengdu 610041,P.R.China)
出处
《生物医学工程学杂志》
北大核心
2025年第6期1303-1308,共6页
Journal of Biomedical Engineering
基金
国家自然科学基金(82202705)
四川大学华西医院专职博士后研发基金(2024HXBH153)。
关键词
金属有机框架材料
伤口愈合
抗菌
皮肤修复
抗感染
Metal-organic frameworks
Wound healing
Antibacterial
Skin repair
Anti-infection
