摘要
以光响应基团-肉桂酸修饰的羧甲基壳聚糖(O-CMC-CA)为壳材,避蚊胺(N,N-二乙基-3-甲基苯甲酰胺,DEET)为芯材,采用离子凝胶法制备了光控缓释DEET纳米微胶囊,并在光照下对微胶囊的光控缓释性能及高保留效果进行研究。利用扫描电子显微镜(SEM)观察了微胶囊的形貌结构,利用红外光谱(FT-IR)分析了壳材的化学结构,用紫外-可见光谱仪(UV-vis)证实了壳材的制备,并测定了包封率及DEET释放量,用热重分析法(TGA)评估了壳材的稳定性,用纳米粒度表面电位分析仪测定微胶囊的粒径及zeta电位。结果表明,采用离子凝胶法制备的微胶囊呈规整的方形形貌,粒径为100~250 nm;在模拟日光照射30 min后,微胶囊24小时释放率提高至10.4%,保留率为89.6%,表明了该微胶囊可实现光控释放且维持DEET稳定性。
Using a photoresponsive group,cinnamic acid,to modify carboxymethyl chitosan(O-CMC-CA)as the shell material and N,N-diethyl-3-methylbenzamide(DEET)as the core material,photo-controlled sustained-release DEET nanocapsules were prepared via an ionic gelation method.The photo-controlled release properties and high retention effects of the nanocapsules under light irradiation were investigated.The morphology of the nanocapsules was observed using scanning electron microscopy(SEM),the chemical structure of the shell material was analyzed with Fourier transform infrared spectroscopy(FT-IR),and the preparation of the shell material was confirmed using an ultraviolet-visible spectrometer(UV-vis).The encapsulation efficiency and DEET release amount were determined,the stability of the shell material was evaluated with thermogravimetric analysis(TGA),and the particle size and zeta potential of the nanocapsules were measured using a nanoparticle size and zeta potential analyzer.The results showed that the nanocapsules prepared by the ionic gelation method exhibited a regular square morphology with a particle size ranging from 100 to 250 nm.After 30 minutes of simulated sunlight irradiation,the 24-hour release rate of the nanocapsules increased to 10.4%,with a retention rate of 89.6%,indicating that the nanocapsules can achieve photo-controlled release while maintaining DEET stability.
作者
申洁
高晓扬
陈光
李少琪
SHEN Jie;GAO Xiaoyang;CHEN Guang;LI Shaoqi(School of Chemistry and Chemical Engineering,Shaanxi University of Science and Technology,Xi'an 710021,China;Guangzhou Chenghao Aroma Technology Co.Ltd.,Guangzhou 511400,China)
出处
《广州化学》
2025年第6期12-17,I0001,共7页
Guangzhou Chemistry
基金
国家自然科学基金(22174090,214750747)
陕西省高层次人才创新长期项目(陈光)
国家外国专家计划高端项目(G2021041002L)。
