摘要
目的探讨人类免疫缺陷病毒(human immunodeficiency virus,HIV)/获得性免疫缺陷综合征(acquired immune deficiency syndrome,AIDS)患者心电图异常情况及其影响因素。方法纳入680例HIV/AIDS患者,对所有患者进行心电图检查并统计异常情况。根据心电图检查结果将患者分为异常组(455例)与正常组(225例),并采用单因素及多因素Logistic回归分析,筛选心电图异常的独立危险因素。结果在680例患者中,共455例存在心电图异常,异常率66.91%。单因素Logistic回归分析显示,两组在吸烟史、肺部感染、CD4^(+)T细胞计数、CD8^(+)T细胞计数、抗病毒治疗方案及高效抗反转录病毒治疗(highly active antiretroviral therapy,HAART)时间上比较,差异均有统计学意义(均P<0.01)。多因素Logistic回归分析进一步确认,吸烟史、合并肺部感染、CD4^(+)T细胞<200个/μL、CD8^(+)T细胞<500个/μL、接受HAART以及HAART时间≥2年是心电图异常的独立危险因素。结论HIV/AIDS患者心电图异常发生率较高,且受免疫状态、合并感染、治疗情况等多种因素影响。临床应督促患者严格戒烟,积极控制炎症(如肺部感染),并尽早开展规范抗病毒治疗,同时加强定期心电图监测,以改善患者预后。
Objective To investigate the prevalence and influencing factors of electrocardiogram(ECG)abnormalities in patients with human immunodeficiency virus(HIV)/acquired immune deficiency syndrome(AIDS).Methods A total of 680 HIV/AIDS patients were enrolled in this study.All patients underwent ECG examination,and the incidence of abnormalities was recorded.Based on the ECG results,patients were categorized into an abnormal group(n=455)and a normal group(n=225).Univariate and multivariate Logistic regression analyses were employed to identify independent risk factors for ECG abnormalities.Results Among the 680 patients,ECG abnormalities were detected in 455 cases,yielding an abnormality rate of 66.91%.Univariate Logistic regression analysis revealed that the two groups showed statistically significant differences in smoking history,pulmonary infection,CD4^(+)T-cell count,CD8^(+)T-cell count,antiretroviral therapy regimen,and the duration of highly active antiretroviral therapy(HAART)(all P<0.01).Multivariate Logistic regression analysis further confirmed that smoking history,co-existing pulmonary infection,CD4^(+)T-cell count<200 cells/μL,CD8^(+)T-cell count<500 cells/μL,receiving HAART,and a HAART duration of≥2 years were independent risk factors for ECG abnormalities.Conclusion The incidence of ECG abnormalities is high among HIV/AIDS patients,and is influenced by various factors,including immune status,co-infections and treatment-related factors.Clinically,it is essential to urge patients to quit smoking strictly,actively manage inflammatory conditions(such as pulmonary infection),initiate standardized antiretroviral therapy as early as possible,and strengthen regular ECG monitoring to improve their prognosis.
作者
熊宇
张在勇
李景隆
童裕维
鲁欢
XIONG Yu;ZHANG Zaiyong;LI Jinglong;TONG Yuwei;LU Huan(Department of Electrocardiogram,Guangzhou Eighth People's Hospital,Guangzhou Medical University,Guangzhou Guangdong 510440,China;Department of Cardiology,Guangzhou Eighth People's Hospital,Guangzhou Medical University,Guangzhou Guangdong 510440,China)
出处
《实用心电与临床诊疗》
2025年第6期835-838,共4页
PRACTICAL ELECTROCARDIOLOGY AND CLINICAL TREATMENT
关键词
人类免疫缺陷病毒
获得性免疫缺陷综合征
心电图
危险因素
human immunodeficiency virus
acquired immune deficiency syndrome
electrocardiogram
risk factor
