摘要
目的估算1起X射线局部受照事故所致放射性皮炎患者的生物剂量。方法采集患者末次受照后54和102 d周围血进行淋巴细胞染色体畸变分析,采用文献报道的4条X射线染色体畸变剂量-效应曲线估算患者的生物剂量,并采用Dolphin′s模型和时间校正系数重建患者的受照剂量。结果患者末次受照后54和102 d染色体畸变率分别为1.00%和0.40%。4条X射线染色体畸变剂量-效应曲线估算患者末次受照后54 d的局部受照剂量为3.59~10.51 Gy,经时间校正的全身照射等效剂量为0.27~0.87 Gy;估算末次受照后102 d的局部受照剂量为2.24~6.64 Gy,经时间校正的全身照射等效剂量为0.12~0.60 Gy,与54 d估算的受照剂量存在差距。2种方法估算的生物剂量均低于物理剂量(29.43 Gy)。结论本研究选择的4条不同曲线估算患者的局部生物剂量各不相同;延迟采血会导致生物剂量估算值降低。为提高剂量估算的准确性与可靠性,应在事故发生后尽早抽血采样;同时,针对复杂照射模式的生物剂量估算方法仍有待研究,以提升辐射事故应急响应的准确性。
Objective To estimate the biological dose in a patient who developed radiation dermatitis after a local X-ray exposure incident.Methods Peripheral blood samples,which were used to performed lymphocyte chromosome aberration analysis,were collected from the patient at 54 and 102 days after the last exposure.Biological dose in the patient was estimated using four published X-ray dose-effect calibration curves for chromosomal aberrations.The absorbed dose in the patient was reconstructed using Dolphin′s model and time correction factors.Results The abnormal rates of chromosome aberration at 54 and 102 days after exposure were 1.00%and 0.40%,respectively.Based on the four calibration curves,the estimated local exposure dose at 54 day ranged from 3.59 to 10.51 Gy,and the time-corrected whole-body equivalent dose ranged from 0.27 to 0.87 Gy.The local dose estimated at 102 days ranged from 2.24 to 6.64 Gy,with a time-corrected whole-body equivalent dose of 0.12 to 0.60 Gy,which differed from the day-54 estimates.The biological doses estimated by both methods were lower than the physical dose(29.43 Gy).Conclusion The estimation of local biological dose of patient various in four dose-effect curves selected in this study.Delayed blood sampling will lead to underestimate biological dose.Early blood collection after radiation incidents is critical to ensure accuracy and reliability.Moreover,biological dose reconstruction methods for complex exposure scenarios require further research to improve the accracy of emergency response in radiation accidents.
作者
刘志芳
彭颖仪
刘小莲
农骐郢
刘秋英
赵娜
刘晓勇
黄伟旭
LIU Zhifang;PENG Yingyi;LIU Xiaolian;NONG qiying;LIU Qiuying;ZHAO Na;LIU Xiaoyong;HUANG Weixu(Guangdong Province Hospital for Occupational Disease Prevention and Treatment,Guangzhou,Guangdong 510300,China)
出处
《中国职业医学》
2025年第4期410-415,共6页
China Occupational Medicine
基金
广东省医学科学技术研究基金(B2020180)。
关键词
局部受照
延迟采血
染色体畸变
生物剂量估算
Local exposure
Delayed blood collection
Chromosome aberration
Biological dose estimation
