摘要
冠状病毒(coronaviruses,CoVs)是一种可感染多种宿主的正链RNA病毒,目前已发现人冠状病毒(human coronavirus,HCoV)、严重急性呼吸综合征冠状病毒(severe acute respiratory syndrome coronavirus,SARS-CoV)、中东呼吸综合征冠状病毒(Middle East respiratory syndrome coronavirus,MERS-CoV)、SARS-CoV-2等多种可感染人类的CoVs。其中,SARS-CoV-2主要引发急性传染性新型冠状病毒肺炎(coronavirus disease 2019,COVID-19),严重威胁人类健康,已成为全球主要公共卫生问题之一。目前,已有部分SARS-CoV-2疫苗或药物上市,但存在需多次注射及部分人群不适用等缺点,亟需开发安全性好、副作用低的新型药物。乳铁蛋白(lactoferrin,LF)作为一种天然铁结合糖蛋白,具有广谱抗病毒、抗炎、免疫调节等功能。本文就LF的主要生物学功能及其抗HCoV作用的研究进展作一综述,以期为LF应用于HCoV感染的临床防治提供参考。
Coronaviruses(CoVs)are plus-stranded RNA viruses that can infect a variety of hosts.Currently,several CoVs have been found to cause human disease,such as human coronavirus(HCoV),severe acute respiratory syndrome coronavirus(SARS-CoV),Middle East respiratory syndrome coronavirus(MERS-CoV),and SARS-CoV-2.Among them,SARS-CoV-2 mainly causes acute infectious coronavirus disease 2019(COVID-19),which seriously threatens human health and has become one of the major public health problems in the world.At present,some SARS-CoV-2 vaccines or drugs have been marketed,but there are shortcomings such as requiring multiple injections and being not applicable to some people.There is an urgent need to develop new drugs with good safety and low side effects.Lactoferrin(LF),a natural iron-binding glycoprotein,has broad-spectrum antiviral,anti-inflammatory and immunomodulatory functions.In this paper,the main biological functions of LF and the research progress on its anti-HCoV effects are reviewed,in order to provide reference for the application of LF in the clinical prevention and treatment of HCoV infection.
作者
赵钰
舒星富(综述)
张海霞
马忠仁(审校)
ZHAO Yu;SHU Xingfu;ZHANG Haixia;MA Zhongren(Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission,Biomedical Research Center,Northwest Minzu University,Lanzhou 730030,Gansu Province,China)
出处
《中国生物制品学杂志》
2025年第11期1387-1392,共6页
Chinese Journal of Biologicals
基金
甘肃省自然科学基金项目(23JRRA717)
2023年度甘肃省教育厅高等学校创新基金项目(2023B-059)
西北民族大学中央高校基本科研业务费专项资金(31920230165)
西北民族大学2025年度研究生科研创新项目(31920250001-8)。
关键词
乳铁蛋白
冠状病毒
严重急性呼吸综合征冠状病毒-2
抗病毒
免疫调节
Lactoferrin(LF)
Coronavirus(Co V)
Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)
Antiviral
Immunoregulation
