摘要
脓毒症是宿主对感染导致的机体反应失调引起的危及生命的器官功能障碍,其中免疫反应是脓毒症失调的核心。白细胞介素(IL)-10是脓毒症免疫反应过程中的重要细胞因子之一。本文围绕IL-10在脓毒症发生发展及其早期诊断、预后以及治疗的最新研究进行简要综述,以提高临床医生对IL-10在脓毒症早期诊断、治疗和预后评估中作用的认识。
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection,with immune dysregulation serving as the central mechanism.Interleukin-10,a pivotal cytokine in the immunopathological cascade of sepsis,plays dual roles in balancing inflammatory and anti-inflammatory responses.This article provided a concise review of the latest research advances regarding the role of interleukin-10 in the pathogenesis,early diagnosis,prognostic evaluation,and therapeutic strategies of sepsis,aiming to enhance clinical understanding of its diagnostic,therapeutic,and prognostic implications in sepsis management.
作者
曾元雄
林晟
王世彪
宁铂涛
Zeng Yuanxiong;Lin Sheng;Wang Shibiao;Ning Botao(Department of Critical Care Medicine,Fujian Children's Hospital(Shanghai Children's Medical Center Fujian Hospital),Fuzhou 350005,China;Department of Pediatric Critical Care Medicine,Clinical College of Women and Children,Fujian Medical University,Fuzhou 350005,China;Department of Pediatric Intensive Care Unit,Children's Medical Center,School of Medicine,Shanghai Jiaotong University,Shanghai 200127,China)
出处
《中国小儿急救医学》
2025年第10期783-788,共6页
Chinese Pediatric Emergency Medicine
基金
国家自然科学基金面上项目(82371770)
上海市浦东新区科技发展基金事业单位民生科研专项(PKJ2023-Y46)。
