摘要
为探究动物双歧杆菌乳亚种BGI-N3对肥胖症的潜在益生作用及机制,通过体外试验评估BGI-N3在消化道中的耐受性,并构建高脂饮食诱导的肥胖症大鼠模型以评估BGI-N3的益生作用。结果表明:BGI-N3对胃肠消化液有较强耐受能力,在人工胃液、人工肠液、0.3%胆盐中的存活率均超过90%。在高脂饮食诱导的肥胖症大鼠模型中,相较于模型对照组,BGI-N3干预组大鼠体质量增加量降低25.90%(P<0.01),食物利用率降低26.90%(P<0.01),附睾脂肪和肾周脂肪质量分别降低45.90%(P<0.001)和61.60%(P<0.001)。此外,BGI-N3的干预显著改善了大鼠肝脏脂肪变性及氧化应激水平,抑制了系统性炎症反应,并显著降低了血清总胆固醇(P<0.001)及甘油三酯(P<0.001)水平。研究结果为动物双歧杆菌乳亚种BGI-N3作为体质量管理相关膳食补充剂的开发提供了科学依据,并为肥胖症及其并发症的预防和治疗提供了新策略。
To explore the potential probiotic effects of Bifidobacterium animalis subsp.lactis BGI-N3 on obesity and its underlying mechanisms,the study assessed the tolerance of BGI-N3 in the digestive tract through in vitro experiments and constructed a high fat diet-induced obesity rat model to assess the probiotic effects of BGI-N3.The results showed that BGI-N3 exhibited strong tolerance to gastrointestinal digestive fluids,with a survival rate exceeding 90%in artificial gastric juice,artificial intestinal fluid,and 0.3%bile salts.In the HFD-induced obesity rat model,compared with the model control group,the BGI-N3 intervention group showed a 25.90%reduction in body weight gain(P<0.01)and a 26.90%decrease in feed efficiency(P<0.01).Moreover,the masses of epididymal and perirenal fat were reduced by 45.90%(P<0.001)and 61.60%(P<0.001),respectively.Additionally,BGI-N3 supplementation significantly ameliorated hepatic steatosis and oxidative stress,suppressed systemic inflammation,and markedly lowered serum levels of total cholesterol(P<0.001)and triglycerides(P<0.001).These findings provide a scientific basis for the development of Bifidobacterium animalis subsp.lactis BGI-N3 as a dietary supplement related to weight management and offer new strategies for the prevention and treatment of obesity and its complications.
作者
罗强
马志辉
胥晓薇
刘艳红
张海峰
钟一祎
LUO Qiang;MA Zhihui;XU Xiaowei;LIU Yanhong;ZHANG Haifeng;ZHONG Yiyi(BGI Precision Nutrition(Shenzhen)Technology Co.,Ltd.,Shenzhen 518000,Guangdong)
出处
《中国食品学报》
北大核心
2025年第11期145-154,共10页
Journal of Chinese Institute of Food Science and Technology
基金
深圳市重大科技专项(KCXFZ20240903094006009)。
关键词
动物双歧杆菌乳亚种
高脂饮食
体质量管理
肥胖症
膳食补充剂
Bifidobacterium animalis subsp.lactis
high fat diet
weight management
obesity
dietary supplement
