摘要
贫血是肺结核常见的并发症之一,其流行病学特征呈现显著的地域差异和人口差异。结核分枝杆菌通过影响宿主免疫系统功能、机体铁代谢水平和慢性炎症特性等原因造成肺结核患者贫血。贫血与肺结核的发生、发展密切相关,是肺结核进展和死亡的独立危险因素。临床应将抗结核治疗与纠正贫血措施紧密结合,深入探究其发病机制和相关危险因素,寻找有效干预措施,为肺结核患者的精准治疗提供理论依据。
Anemia is a prevalent complication of pulmonary tuberculosis,exhibiting marked regional and demographic variations in its epidemiological characteristics.Mycobacterium tuberculosis induces anemia in pulmonary tuberculosis patients by impairing host immune function,altering systemic iron metabolism,and exacerbating chronic inflammatory responses.Anemia is intricately linked to the onset and progression of pulmonary tuberculosis and serves as an independent risk factor for disease deterioration and mortality.Clinically,anti-tuberculosis therapy should be integrated with strategies to address anemia.Furthermore,a deeper understanding of the pathogenesis and associated risk factors is warranted to identify effective interventions to provide a theoretical foundation for the precise management of pulmonary tuberculosis patients.
作者
齐畅
蒋波笛
孟祥红
QI Chang;JIANG Bodi;MENG Xianghong(Medical College of Basic Medicine,Jiamusi University,Jiamusi,Heilongjiang 154007;Department of Blood Transfusion Medicine,8th Medical Center of PLA General Hospital,Beijing 100091)
出处
《临床输血与检验》
2025年第6期876-881,共6页
Journal of Clinical Transfusion and Laboratory Medicine
基金
国家卫健委科技专项课题(No.2021KYSHX02302)资助。
关键词
肺结核
贫血
结核分枝杆菌
免疫紊乱
铁调素
微量元素
铁代谢
Pulmonary tuberculosis
Anemia
Mycobacterium tuberculosis
Immune dysfunction
Hepcidin Trace elements
Iron metabolism
