摘要
妇科恶性肿瘤的发病率和病死率逐年升高,严重威胁女性生命健康。中医药在妇科恶性肿瘤综合治疗中应用广泛,作为最常见的中药活性成分,中药多糖抗妇科恶性肿瘤的作用机制包括调控肿瘤相关信号通路,阻滞肿瘤细胞周期,抑制肿瘤细胞转移和侵袭,促进肿瘤细胞凋亡、自噬和铁死亡,抑制肿瘤细胞免疫逃逸和上皮-间质转化,调节癌基因和抑癌基因表达,以及作为高效的药物载体发挥减毒增效作用等。但中药多糖的临床应用仍然面临生物利用度低、分离提取复杂等挑战,未来有必要进行进一步的基础研究和临床试验,以期为中药创新药的开发提供参考,促进中西医结合治疗妇科恶性肿瘤在临床中的广泛应用。
The incidence and mortality rates of gynecological malignancies are increasing year by year,posing a serious threat to women′s health.Traditional Chinese medicine is widely used in the comprehensive treatment of gynecological malignancies.As the most common active components of traditional Chinese medicine,the mechanisms of Chinese herbal polysaccharides against gynecological malignancies include regulating tumor-related signaling pathways,arresting the tumor cell cycle,inhibiting tumor cell metastasis and invasion,promoting tumor cell apoptosis,autophagy and ferroptosis,suppressing tumor cell immune escape and epithelial-mesenchymal transition,regulating the expression of oncogenes and tumor suppressor genes,and serving as efficient drug carriers to reduce toxicity and enhance efficacy.However,the clinical application of traditional Chinese medicine polysaccharides still faces challenges such as low bioavailability and complex separation and extraction.In the future,it is necessary to conduct further basic research and clinical trials to provide references for the development of innovative traditional Chinese medicine and promote the wide clinical application of the combination of traditional Chinese and Western medicine in the treatment of gynecological malignancies.
作者
高越
石百超
余健楠
张丽倩
王宇
吴效科(审校)
GAO Yue;SHI Bai-chao;YU Jian-nan;ZHANG Li-qian;WANG Yu;WU Xiao-ke(Heilongjiang University of Chinese Medicine,Harbin 150040,China;Department of Gynecology,First Affiliated Hospital,Heilongjiang University of Chinese Medicine,Harbin 150040,China)
出处
《国际妇产科学杂志》
2025年第6期685-689,707,共6页
Journal of International Obstetrics and Gynecology
基金
黑龙江省卵巢疾病临床医学研究中心(LC2020R009)
中医药循证能力提升项目(国中医药科技中药便函〔2023〕24号)。
关键词
多糖类
中药化学成分
宫颈肿瘤
卵巢肿瘤
子宫内膜肿瘤
Polysaccharides
Chemical compositions(TCD)
Uterine cervical neoplasms
Ovarian neoplasms
Endometrial neoplasms
