摘要
目的 探讨自拟三金二石三子排石汤治疗西宁地区石淋患者的临床疗效。方法 选取2023年1月—2024年12月青海省中医院收治的气滞血瘀湿热型石淋(泌尿系结石)患者100例,按随机数字表法分为对照组和研究组,每组各50例。对照组给予常规西药治疗,研究组在对照组治疗的基础上联合自拟三金二石三子排石汤治疗。治疗20~25 d后,观察比较两组患者临床疗效、不良反应情况、复发率、结石排出时间、排尽时间、疼痛缓解时间,治疗前后中医证候积分、肾功能[血肌酐(Serum creatinine,Scr)、尿素氮(Blood urea nitrogen,BUN)]。结果 治疗后研究组临床总有效率96.00%(48/50)明显高于对照组84.00%(42/50),差异有统计学意义(P<0.05)。治疗后两组患者中医证候积分均较治疗前降低,差异有统计学意义(P<0.05);且研究组中医证候积分较对照组明显降低,差异有统计学意义(P<0.05)。治疗后研究组结石排出时间、排尽时间及疼痛缓解时间均短于对照组,差异有统计学意义(P<0.05)。治疗后两组患者Scr、BUN水平均较治疗前降低,差异有统计学意义(P<0.05);且研究组Scr、BUN水平均较对照组明显降低,差异有统计学意义(P<0.05)。治疗期间,两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。随访一年,研究组复发率为3.85%(1/26)明显低于对照组27.78%(5/18),差异有统计学意义(P<0.05)。结论 邓尔禄教授自拟三金二石三子排石汤治疗西宁地区气滞血瘀湿热型石淋患者疗效确切,可缓解患者临床症状,提高排石效率,改善肾功能,降低复发风险,且安全性良好。
Objective To explore the clinical efficacy of self-formulated Sanjin Ershi Sanzi Paishi Decoction on stone leaching in Xining.Methods A total of 100 patients with stone leaching(urinary calculi)of qi stagnation,blood stasis,and dampness-heat type treated at Qinghai Provincial Hospital of Traditional Chinese Medicine from January 2023 to December 2024 were selected and divided into a control group and a study group by the random number table method,with 50 cases in each group.Both groups received routine western medicine,while the study group additionally received self-formulated Sanjin Ershi Sanzi Paishi Decoction.After treatment for 20~25 days,clinical efficacy,adverse reaction,recurrence rate,stone excretion time,stone clearance time,and pain relief time were compared between the two groups,as well as aspects below before and after treatment:traditional Chinese medicine(TCM)syndrome scores and renal function[serum creatinine(Scr)and blood urea nitrogen(BUN)].Results After treatment,total clinical efficacy was 96.00%(48/50)in the study group,higher than 84.00%(42/50)in the control group(P<0.05).TCM syndrome scores were decreased in both groups(P<0.05),with these scores being significantly lower in the study group(P<0.05).Additionally,stone excretion time,stone clearance time,and pain relief time were shorter in the study group(P<0.05).Scr and BUN levels were decreased in both groups(P<0.05),with these scores being significantly lower in the study group(P<0.05).During treatment,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).After a follow-up of 1 year,the recurrence rate was 3.85%(1/26)in the study group,lower than that in the control group(27.78%5/18)(P<0.05).Conclusion Sanjin Ershi Sanzi Paishi Decoction,self-formulated by Professor DENG Erlu,has a definite curative effect on stone leaching of qi stagnation,blood stasis,and dampness-heat type in Xining.The Decoction can alleviate clinical symptoms,promote stone clearance efficiency,improve renal function,and reduce recurrence risk,with ideal safety.
作者
王玲
李富鑫
宗玮
祁永福
喇登海
金彩元
李兴措
马勇
WANG Ling;LI Fu-xin;ZONG Wei;QI Yong-fu;LA Deng-hai;JIN Cai-yuan;LI Xing-cuo;MA Yong(Qinghai Provincial Hospital of Traditional Chinese Medicine,Xining Qinghai 810000;Qinghai Special Hospital of Cardio-Cerebrovascular Diseases,Xining Qinghai 810012)
出处
《世界中西医结合杂志》
2025年第11期2257-2261,共5页
World Journal of Integrated Traditional and Western Medicine
基金
青海省科技计划项目(2023-SF-108)。
关键词
自拟三金二石三子排石汤
西宁地区
气滞血瘀湿热型
石淋
泌尿系结石
Self-Formulated Sanjin Ershi Sanzi Paishi Decoction
Xining
Qi Stagnation,Blood Stasis,and Dampness-Heat Type
Stone Leaching
Urinary Stone
