摘要
目的 观察健脾祛湿方联合左西替利嗪治疗脾虚湿盛型湿疹患者的临床疗效及对其血清学指标的影响。方法 选取2022年5月—2024年5月在江南大学附属医院就诊的脾虚湿盛型湿疹患者90例,按随机数字表法分为对照组、观察组,每组各45例。对照组使用左西替利嗪进行治疗,观察组在对照组的基础上加用健脾祛湿方治疗。治疗2周后,观察比较两组患者的临床疗效、不良反应发生情况,治疗前后中医证候积分、湿疹面积严重度指数(Eczema area and severity index,EASI)评分、瘙痒程度评分、炎症因子[白介素-4(Interleukin-4,IL-4)、白介素-5(Interleukin-5,IL-5)、白介素-10(Interleukin-10,IL-10)]水平。结果 观察组患者治疗总有效率为95.56%(43/45)与对照组的80.00%(36/45)比较,差异有统计学意义(P<0.05)。治疗后两组患者皮损暗淡、皮肤瘙痒、伴水疱、胃脘满闷积分均低于治疗前,差异有统计学意义(P<0.05);且观察组患者皮损暗淡、皮肤瘙痒、伴水疱、胃脘满闷积分均明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者EASI评分、瘙痒程度评分均低于治疗前,差异有统计学意义(P<0.05);且观察组患者EASI评分、瘙痒程度评分均明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者IL-4、IL-5、IL-10水平均低于治疗前,差异有统计学意义(P<0.05);且观察组患者炎症因子水平明显低于对照组,差异有统计学意义(P<0.05)。治疗期间,两组患者不良反应发生率分别为11.11%(5/45)、15.56%(7/45),差异无统计学意义(P>0.05)。结论 健脾祛湿方联合左西替利嗪治疗脾虚湿盛型湿疹的效果明显,可有效改善患者临床症状,减轻炎症反应,且无明显不良反应增加。
Objective To observe the clinical efficacy of the Jianpi Qushi Decoction combined with levocetirizine for eczema with spleen deficiency and dampness abundance,and the combined treatment's effect on patients'serological indicators.Methods A total of 90 eczema patients with spleen deficiency and dampness abundance treated at the Affiliated Hospital of Jiangnan University from May 2022 to May 2024 were selected and divided into a control group and an observation group by the random number table method,with 45 cases in each group.Both groups received levocetirizine,while the observation group additionally received Jianpi Qushi Decoction.After treatment for two weeks,clinical efficacy and the occurrence of adverse reactions were compared,as well as aspects below before and after treatment:changes in traditional Chinese medicine(TCM)syndrome scores,eczema area and severity index(EASI)scores,pruritus severity scores,and inflammatory factors[interleukin-4(IL-4),interleukin-5(IL-5)and interleukin-10(IL-10)].Results There were statistically significant differences in total therapeutic effective rate between the observation group(95.56%43/45)and the control group(80.00%36/45)(P<0.05).After treatment,the scores of dull skin lesions,skin itching,blisters,as well as fullness and oppression in the epigastric region were decreased in both groups,with these scores being significantly lower in the observation group(P<0.05).Similarly,the EASI and pruritus severity scores were decreased in both groups(P<0.05),with these scores being significantly lower in the observation group(P<0.05).Additionally,IL-4,IL-5,and IL-10 levels were decreased in both groups(P<0.05),with the inflammatory factor levels being significantly lower in the observation group(P<0.05).During treatment,the incidence rates of adverse reactions in the two groups were 11.11%(5/45)and 15.56%(7/45),respectively,without statistical significance(P>0.05).Conclusion Jianpi Qushi Decoction combined with levocetirizine is significant for eczema with spleen deficiency and dampness abundance.The combined treatment can effectively improve the clinical symptoms of patients and reduce inflammatory responses,without a significant increase in adverse reactions.
作者
蒋蓓
朱永丹
华愉教
JIANG Bei;ZHU Yong-dan;HUA Yu-jiao(Affiliated Hospital of Jiangnan University,Wuxi Jiangsu 214101)
出处
《世界中西医结合杂志》
2025年第11期2228-2232,共5页
World Journal of Integrated Traditional and Western Medicine
基金
江苏省精益化用药-石药专项科研基金项目(JY202235)。
关键词
健脾祛湿方
左西替利嗪
脾虚湿盛型湿疹
炎症反应
Jianpi Qushi Decoction
Levocetirizine
Eczema with Spleen Deficiency and Dampness Abundance
Inflammatory Response
