摘要
粪菌移植(fecal microbiota transplantation,FMT)是将健康供体粪便中的微生物移植到患者胃肠道中,直接改变患者肠道微生物群,使其成分正常化并达到治疗效果的一种治疗方法。慢性腹泻与肠道微生物群密切相关,肠道微生物群失衡可导致慢性腹泻的发生和发展,FMT是治疗慢性腹泻的重要有效手段。本文综述了慢性腹泻与肠道微生物群之间的相互关系、FMT技术在慢性腹泻中的研究及应用进展、存在的问题和对未来的展望,为FMT治疗慢性腹泻的进一步研究提供参考。
Fecal microbiota transplantation(FMT)is a therapeutic method in which microorganisms are transplanted from healthy donors’feces into the gastrointestinal tract of patients,to directly change their intestinal microbiota,normalize its composition,and achieve therapeutic effects.Chronic diarrhea is closely associated with the gut microbiota and an imbalance in the gut microbiota can lead to the occurrence and progression of chronic diarrhea.FMT is an effective approach for the treatment of chronic diarrhea.This review summarizes the relationship between chronic diarrhea and the gut microbiota and considers research advancements and applications of FMT technology for managing chronic diarrhea.We also address the prevailing challenges and future prospects,to provide a reference for further studies of FMT for the treatment of chronic diarrhea.
作者
钱子瑶
李鹤龄
王宏
QIAN Ziyao;LI Heling;WANG Hong(Institute of Primate Translational Medicine,Kunming University of Science and Technology,Kunming 650500,China;Yunnan Key Laboratory of Primate Biomedical Research,Kunming 650500,China)
出处
《中国实验动物学报》
北大核心
2025年第11期1663-1671,共9页
Acta Laboratorium Animalis Scientia Sinica
基金
国家自然科学基金项目(31960121)。
关键词
粪菌移植
肠道微生物群
慢性腹泻
研究进展
fecal microbiota transplantation
gut microbiota community
chronic diarrhea
research progress
