摘要
目的基于CNKI和Web of Science(WOS)数据库分析近十年来国内外对炎症与脑小血管病(CSVD)相关研究的发展脉络及研究热点,为后续进一步的研究提供参考。方法检索CNKI和WOS数据库中炎症与CSVD的相关研究文献,时间设置为2015年1月1日-2025年4月1日。运用CiteSpace 6.3.R1、Excel等软件对所纳入的文献进行作者、机构和关键词可视化分析。结果纳入CNKI数据库文献237篇,WOS数据库文献343篇。整体来看,CNKI和WOS数据库的发文量均呈上升趋势。从国家分布来看,发文量前3位的国家分别是中国、美国和英国。国内外核心作者群体已初步形成,其研究方向呈现出一定的特征:国内学者更侧重于临床表征与流行病学调查,而国际团队则更多聚焦于分子机制与创新疗法探索。关键词共现与突现分析进一步揭示,炎症在CSVD的病理生理过程中发挥核心驱动作用,是其发生和发展的关键病理机制。结论炎症与CSVD方面的研究目前已得到广泛关注,但仍需实现知识体系的当代更新,联系当下的热点与趋势,为临床提供更精准化的诊疗方向。
Objective To analyze the development and research hotspots of inflammation and cerebral small vessel disease(CSVD)in China and abroad in the past decade based on CNKI and Web of Science(WOS)databases,and to provide reference for further research.Methods The related research literatures on inflammation and CSVD in CNKI and WOS databases were searched from January 1,2015 to April 1,2025.CiteSpace 6.3.R1,Excel and other software were used to analyze the authors,institutions and keywords of the included literature.Results A total of 237 literatures in CNKI database and 343 literatures in WOS database were included.On the whole,the number of papers published in CNKI and WOS databases was on the rise.From the perspective of country distribution,the top three countries with the largest number of publications were China,the United States and the United Kingdom.The core author group at home and abroad had been initially formed,and its research direction showed certain characteristics:domestic scholars focused more on clinical characterization and epidemiological investigation,while international teams focused more on molecular mechanism and innovative therapy exploration.Keyword co-occurrence and burst analysis further revealed that inflammation played a core driving role in the pathophysiological process of CSVD and was a key pathological mechanism for its occurrence and development.Conclusion At present,the research on inflammation and CSVD has received extensive attention,but it is still necessary to realize the contemporary update of the knowledge system,contact the current hotspots and trends,and provide more accurate diagnosis and treatment direction for clinical practice.
作者
尹诗雨
刘建辉
YIN Shiyu;LIU Jianhui(The Second Clinical Medical College,Guizhou University of Traditional Chinese Medicine,Guizhou 550025,Guiyang,China;Department of Neurology,the Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550003,Guizhou,China)
出处
《医学信息》
2025年第23期8-15,共8页
Journal of Medical Information
