摘要
目的 观察畅脉乐胶囊用于气虚血瘀型不稳定型心绞痛(unstable angina pectoris,UAP)患者中的疗效,探讨可能的药理机制。方法 选取2021年1月—2022年1月在福建中医药大学附属第二人民医院住院治疗的70例气虚血瘀型UAP患者为研究对象。以随机数字表法分为对照组(n=35)与治疗组(n=35)。对照组根据临床指南指导开展常规药物治疗,治疗组加服畅脉乐胶囊。分析2组治疗前后中医证候积分、临床疗效、西雅图心绞痛量表积分、组织激肽释放酶结合蛋白(kallistatin,KAL)及血栓弹力图中的最大振幅(maximum amplitude,MA)值的变化。结果 治疗后,治疗组中医证候积分、西雅图心绞痛量表积分分别为(6.35±1.25)分、6.00(2.00,8.00)分,低于对照组的(10.00±3.98)分、8.00(5.00,12.00)分,差异有统计学意义(P<0.001)。治疗组治疗总有效率为97.06%,高于对照组的75.75%,差异有统计学意义(P<0.05)。治疗后,治疗组KAL为(39.81±4.83)μg/m L,高于对照组的(36.67±6.20)μg/m L,差异有统计学意义(P<0.05)。治疗后,治疗组MA值为(64.29±4.00)mm,低于对照组的(67.04±4.68)mm,差异有统计学意义(P<0.05)。结论 畅脉乐胶囊治疗气虚血瘀型UAP患者的效果确切,能够改善症状,提高KAL水平,降低MA值。
Objective To observe the therapeutic effect of Changmaile capsules in patients with unstable angina pectoris(UAP)of qi deficiency and blood stasis type,and to explore the possible pharmacological mechanism.Methods A total of 70 patients with UAP of qi deficiency and blood stasis type who were hospitalized in the Second Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine from January 2021 to January 2022 were selected as the research subjects.The patients were divided into the control group(n=35)and the treatment group(n=35)by random number table method.The control group was given conventional drug therapy according to clinical guidelines,and the treatment group was given Changmaile capsule.The traditional Chinese medicine syndrome score,clinical efficacy,Seattle angina score,tissue kalallistatin(KAL)and maximum amplitude(MA)in thromboelastography were analyzed before and after treatment in the two groups.Results After treatment,the traditional Chinese medicine syndrome score and Seattle angina scale score of the treatment group were(6.35±1.25)points and 6.00(2.00,8.00)points respectively,which were lower than(10.00±3.98)points and 8.00(5.00,12.00)points of the control group,and the differences were statistically significant(P<0.001).The total effective rate of treatment in the treatment group was 97.06%,which was higher than 75.75%in the control group,and the difference was statistically significant(P<0.05).After treatment,the KAL of the treatment group was(39.81±4.83)μg/mL,which was higher than(36.67±6.20)μg/mL of the control group,and the difference was statistically significant(P<0.05).After treatment,the MA value of the treatment group was(64.29±4.00)mm,which was lower than(67.04±4.68)mm of the control group,and the difference was statistically significant(P<0.05).Conclusion Changmaile capsules have a definite effect in treating UAP patients with qi deficiency and blood stasis type.They can improve symptoms,increase KAL levels and reduce MA values.
作者
姚锡满
郭进建
YAO Ximan;GUO Jinjian(Department of Cardiology,Fuzhou Traditional Chinese Medicine Hospital,Fuzhou Fujian 350001,China;Department of Cardiology,the Second Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine,Fuzhou Fujian 350001,China)
出处
《中国卫生标准管理》
2025年第18期147-151,共5页
China Health Standard Management
