摘要
目的:基于CiteSpace分析软件对目前国内外肥胖人群肠道菌群分布的相关研究进行可视化分析,以了解当前研究热点和未来研究趋势,为肥胖人群的健康指导提供参考。方法:检索中国知网数据库及Web of Science(WOS)合集2005年1月1日-2025年4月7日收录的主题词为“肥胖”“肠道菌群”的公开发表文献,通过CiteSpace软件等对收集到文献的发表年份、来源、作者、关键词等信息进行可视化分析。结果:根据主题词检索共获得中文文献2482篇和外文文献4274篇,从2007年开始,相关领域的发文量呈现增长趋势,在2022年达到峰值,此后有小幅度下降;在国内外各机构中,以上海交通大学和加州大学在相关领域的发文量最多;期刊载文量方面,相关研究在《中国微生态学杂志》和《Nutrients》的发文量最多;目前国内外均尚未形成核心作者群;研究以“肠道菌群”“肥胖”“益生菌”等为核心,高频词为“高脂饮食”“胰岛素抵抗”“炎症”等,研究多聚焦于精准医疗和跨学科融合。结论:当前研究尚未形成核心作者群,学术共同体建设仍有待加强;精准医疗理念的渗透和跨学科技术融合正在重塑研究范式,宏基因组学、代谢组学与人工智能的结合为个性化干预开辟新路径。未来需加强国际科研协作,深化临床转化,同时构建跨学科研究团队以应对肥胖防治的复杂问题,为制定基于肠道微生态调节的肥胖管理策略提供理论依据。
Objective:Through CiteSpace analysis software,the relevant research on the distribution of intestinal flora in obese people at home and abroad was visually analyzed in this study to understand the current research hotspots and future research trends,so as to provide more reference for the health guidance of obese people.Methods:The publicly published literature with the keywords“obesity”and“intestinal flora”included in the CNKI database and the core collection of Web of Science(WOS)from January 1,2005 to April 7,2025 was searched,and the publication year,source,author,keywords and other information of the included literatures were visually analyzed by the CiteSpace software.Results:According to the subject word search,a total of 2482 Chinese articles and 4274 foreign articles were obtained.Since 2007,the number of articles published in related fields had shown an increasing trend,reaching the peak in 2022,and had declined slightly thereafter.Among domestic and foreign institutions,Shanghai Jiaotong University and University of California had issued the most articles in relevant fields.The numbers of related research articles published in Chinese Journal of Microecology or Nutrients were the largest.At present,there is no core author group at home and abroad.The research focused on“intestinal flora”,“obesity”,and“probiotics”,with high-frequency keywords including“high-fat diet”,“insulin resistance”and“inflammation”.In recent years,the research has focused on precision medicine and interdisciplinary integration.Conclusions:The current research has not yet formed a core author group,and the construction of academic community still needs to be strengthened.The penetration of precision medical concepts and the integration of interdisciplinary technologies are reshaping the research paradigm.The combination of metagenomics,metabolomics,and artificial intelligence opens up a new path for personalized intervention.In the future,it is necessary to strengthen international scientific research collaboration,deepen clinical transformation,and build an interdisciplinary research team to deal with the complex problems in the prevention and treatment of obesity,so as to provide theoretical basis for formulating obesity management strategies based on gut microbiome regulation.
出处
《中医临床研究》
2025年第28期123-135,共13页
Clinical Journal Of Chinese Medicine
基金
青海省科技计划项目(2024-ZJ-772):基于膳食结构差异观察高海拔地区母乳乳汁成分对婴儿肠道菌群影响的研究。
