摘要
近年来,非酒精性脂肪性肝病(NAFLD)已经成为危害人类健康的全球性公共卫生问题。肠道菌群的相关研究已成为当今临床医学和生命科学研究中极其重要的热点领域。越来越多的研究表明肠道菌群对机体代谢起到重要作用,一些肠道菌群代谢物如丁酸等可以通过改善肠道屏障、降低胰岛素抵抗、改善脂肪变性、减轻炎症反应等来改善机体代谢紊乱。而LPS等致病因素可能会造成机体的炎症反应、加重胰岛素抵抗、氧化应激和脂质代谢紊乱等,进而诱发NAFLD。本文主要阐述了常见肠道菌群代谢产物与代谢性疾病NAFLD相关表型的相关性,旨在为揭示肠道菌群与NAFLD的关系提供详实参考依据。
In recent years,nonalcoholic fatty liver disease(NAFLD)has become a global public health problem that endangers human health.The related research of intestinal flora has become an extremely important hot field in clinical medicine and life science research.A growing number of studies have shown that intestinal flora plays an important role in the metabolism of the body.Some intestinal flora metabolites such as butyric acid can improve the body's metabolic disorders by improving the intestinal barrier,reducing insulin resistance,improving steatosis,and reducing inflammation.LPS and other pathogenic factors may cause the body's inflammatory response,aggravate insulin resistance,oxidative stress and lipid metabolism disorders,and then induce NAFLD.This article mainly expounds the correlation between common intestinal flora metabolites and NAFLD-related phenotypes of metabolic diseases,aiming to provide a detailed reference for revealing the relationship between intestinal flora and NAFLD.
作者
李梦瑶
伍晓然
徐秋容
王吉
文利新
LI Mengyao;WU Xiaoran;XU Qiurong;WANG Ji;WEN Lixin(Hunan Engineering Research Center of Livestock and Poultry Health Care,College of Veterinary Medicine,Hunan Agricultural University,Changsha 410128,Hunan,China;Changsha Lvye Biotechnology Co.,Ltd.,Changsha 410100,Hunan,China)
出处
《医学信息》
2025年第4期171-175,181,共6页
Journal of Medical Information
基金
国家自然科学基金面上项目(编号:32373079)。
关键词
非酒精性脂肪性肝病
代谢性疾病
菌群代谢物
肠道菌群
Nonalcoholic fatty liver disease
Metabolic diseases
Microbial metabolites
Gut microbiota
