摘要
阿尔茨海默病(Alzheimer’s disease, AD)是常见的神经退行性疾病,目前尚缺乏有效治疗方法。近年研究发现,腐胺作为多胺代谢的核心分子,在AD发生发展中扮演关键角色。本文系统综述了腐胺的神经生物学功能及其在AD中的多重病理机制,包括促进Aβ沉积、诱发氧化应激与线粒体损伤、激活神经炎症及导致突触功能障碍等多个方面。此外,文章还评估了以腐胺代谢为靶点的治疗策略,如抑制其合成关键酶或补充有益多胺等在干预AD进程中的潜力与挑战。本研究为深入理解AD的代谢机制及开发针对多胺系统的治疗手段提供了理论依据。
Alzheimer's disease(AD)is a common neurodegenerative disorder for which effective treatments are still lacking.Recent studies have revealed that putrescine,as a central molecule in polyamine me tabolism,plays a critical role in the onset and progression of AD.This review systematically summarizes the neurobiological functions of putrescine and its multifaceted pathological mechanisms in AD,including the pro motion of Aβdeposition,induction of oxidative stress and mitochondrial damage,activation of neuroinflamma tion,and impairment of synaptic function.Additionally,the article evaluated therapeutic strategies targeting pu trescine metabolism,such as inhibiting its key synthetic enzymes or supplementing beneficial polyamines,in terms of their potential and challenges in intervening with the AD process.This study provides a theoretical ba sis for a deeper understanding of the metabolic mechanisms of AD and the development of therapeutic approach es targeting the polyamine system.
作者
梅笑寒
王群
MEI Xiaohan;WANG Qun(College of Clinical Medicine,Zhengzhou University,Zhengzhou 450001,China;Department of Neurology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450001,China)
出处
《神经损伤与功能重建》
2025年第12期742-746,共5页
Neural Injury and Functional Reconstruction
关键词
阿尔茨海默病
腐胺
病理蛋白
氧化应激
神经炎症
Alzheimer's disease
putrescine
pathological proteins
oxidative stress
neuroinflammation
