摘要
本研究通过正交试验优化苦参、厚朴的提取工艺,确定最佳条件为:提取时间30 min、乙醇浓度60%、料液比1:10(g/mL)。在此条件下,苦参碱提取含量达0.39%,厚朴酚含量为0.76%。将其进一步制备为祛痘精华液,评价显示该产品对痤疮丙酸杆菌抑菌圈直径达15.7 mm,具有显著抑菌作用;抗氧化性能方面,DPPH与ABTS自由基清除率分别为93.09%和94.20%。人体斑贴试验表明其安全性良好,仅1例出现轻微红斑。人体试用结果显示,使用3小时后皮肤油脂减少26.60%,痤疮数量下降32.23%,红斑面积减少27.26%。综上,该中药复方祛痘精华液抑菌、抗氧化及改善痤疮效果显著,安全性高,在功能性祛痘化妆品中具有良好开发前景。
This study optimized the extraction process of Sophora flavescens and Magnolia officinalis through orthogonal experiments,and determined the optimal conditions as follows:extraction time of 30 minutes,ethanol concentration of 60%,and solid-liquid ratio of 1:10(g/mL).Under these conditions,the extraction content of matrine reached 0.39%,and the content of magnolol was 0.76%.The product was further prepared into an acne-removing essence.Evaluation showed that the product had a significant antibacterial effect on Propionibacterium acnes,with an inhibition zone diameter of 15.7 mm.In terms of antioxidant performance,the DPPH and ABTS radical scavenging rates were 93.09%and 94.20%,respectively.The human patch test indicated good safety,with only one case showing mild erythema.The human trial results showed that after 3 hours of use,the skin oil content decreased by 26.60%,the number of acne decreased by 32.23%,and the erythema area decreased by 27.26%.In conclusion,this traditional Chinese medicine compound acne-removing essence has significant antibacterial,antioxidant and acne-improving effects,and high safety,with good development prospects in functional acne-removing cosmetics.
作者
王亚楠
刘一帆
沈煜昊
郭珈玮
刘翠红
黄裕
WANG Yanan;LIU Yifan;SHEN Yuhao;GUO Jiawei;LIU Cuihong;HUANG Yu(Guangzhou Huashang College,Guangzhou,511300,China)
出处
《中国化妆品科学》
2025年第5期105-112,共8页
CHINA COSMETICS SCIENCE
基金
2024年度广州华商学院特色科研项目(编号2024HSTS05)
第三届全国大学生绿色化妆品创新创意大赛泛大湾区赛区配方设计大学组特别奖作品(作品名称:朴韵苦参锦华露,编号NGC-DWQ-032025002)。
关键词
苦参
厚朴
祛痘精华液
抑菌效果
安全性
sophora flavescens
magnolia officinalis
anti-acne essence
antibacterial activity
safety profile
