摘要
目的分析肺结节合并慢性肺病患者的中药饮片处方调整策略及疗效。方法筛选76例肺结节合并慢性肺病患者,随机分为对照组与研究组,每组38例。其中对照组为常规西药治疗,研究组为中药饮片处方调整治疗。比较两组临床疗效、不良反应发生率、中医证候积分、炎性因子[白细胞介素-6(IL-6)、降钙素原(PCT)、C反应蛋白(CRP)]、肺功能指标[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC]。结果与对照组的84.2%、21.1%相比,研究组总有效率97.4%更高,不良反应发生率5.3%更低(P<0.05)。与对照组的(1.55±0.35)、(1.52±0.32)、(1.47±0.47)、(1.26±0.23)分相比,研究组胸痛积分(0.58±0.12)分、气短喘息积分(0.43±0.18)分、咳嗽积分(0.51±0.15)分、口干发热积分(0.66±0.11)分更低(P<0.05)。与对照组的(34.75±8.27)pg/ml、(0.78±0.15)ng/ml、(43.26±3.22)mg/L相比,研究组治疗后IL-6(28.45±6.26)pg/ml、PCT(0.22±0.11)ng/ml、CRP(36.23±2.14)mg/L更低(P<0.05)。与对照组相比,研究组治疗后FEV1、FVC、FEV1/FVC更高(P<0.05)。结论中药饮片处方调整治疗肺结节合并慢性肺病的疗效理想,能尽快改善患者临床症状,恢复肺部基本功能,稳定炎性因子指标,控制不良反应,可推广使用。
Objective To analyze the prescription adjustment strategies and therapeutic effects of traditional Chinese medicine decoction pieces for patients with pulmonary nodules complicated with chronic lung disease.Methods A total of 76 patients with pulmonary nodules complicated with chronic lung disease were selected and divided into two groups:the control group(38 cases)and the research group(38 cases).The control group was treated with conventional Western medicine,while the research group was treated with prescription adjustment of traditional Chinese medicine decoction pieces.Comparing the clinical efficacy,incidence of adverse reactions,traditional Chinese medicine syndrome score,inflammatory factors[interleukin-6(IL-6),procalcitonin(PCT),C-reactive protein(CRP)],and pulmonary function indicators[forced expiratory volume in one second(FEV1),forced vital capacity(FVC),FEV1/FVC]of the two groups.Results Compared with 84.2%and 21.1%of the control group,the research group had higher overall response rate(97.4%)and fewer adverse reactions(5.3%)(P<0.05).Compared with the control group[(1.55±0.35),(1.52±0.32),(1.47±0.47),and(1.26±0.23)points],the scores of chest pain(0.58±0.12)points,shortness of breath and wheezing(0.43±0.18)points,cough(0.51±0.15)points,and dry mouth and fever(0.66±0.11)points were lower in the research group(P<0.05).Compared with the control group[(34.75±8.27)pg/ml,(0.78±0.15)ng/ml,and(43.26±3.22)mg/L],the levels of IL-6(28.45±6.26)pg/ml,PCT(0.22±0.11)ng/ml,and CRP(36.23±2.14)mg/L were lower in the research group after treatment(P<0.05).Compared with the control group,the FEV1,FVC,and FEV1/FVC levels in the research group were higher after treatment(P<0.05).Conclusion The prescription adjustment of traditional Chinese medicine decoction pieces has an ideal therapeutic effect on pulmonary nodules combined with chronic lung disease.It can improve the clinical symptoms of patients as soon as possible,restore the basic function of the lungs,stabilize inflammatory factor indicators,and control adverse reactions.It can be promoted for use.
作者
赵军
黄学平
ZHAO Jun;HUANG Xue-ping(Department of Pharmacy,Baoying County Hospital of Traditional Chinese Medicine,Yangzhou 225800,China)
出处
《中国现代药物应用》
2026年第3期125-128,共4页
Chinese Journal of Modern Drug Application
关键词
肺结节
慢性肺病
中药饮片处方
调整策略
临床疗效
安全性
Pulmonary nodules
Chronic lung disease
Traditional Chinese medicine decoction pieces
Adjustment strategies
Clinical efficacy
Safety
