摘要
目的探讨小建中汤联合匹维溴铵治疗脾虚型功能性消化不良(FD)上腹痛综合征(EPS)的有效性、安全性。方法选取48例脾虚型功能性消化不良EPS患者,采用随机数字表法分为观察组(24例)、对照组(24例)。观察组采用小建中汤+匹维溴铵治疗,对照组采用匹维溴铵治疗。比较两组患者视觉模拟评分法(VAS)评分、中医症状评分、心理状态[医院焦虑抑郁量表(HADS)评分]、药物不良反应发生率。结果治疗4周后,两组VAS评分均显著下降,且观察组VAS评分(1.29±1.23)分较对照组的(2.71±1.97)分下降更显著,具有统计学差异(P<0.05)。治疗4周后,两组中医症状评分均显著下降,且观察组中医症状评分(0.92±0.88)分较对照组的(1.88±1.54)分下降更显著,具有统计学差异(P<0.05)。治疗4周后,两组HADS评分均显著下降,且观察组HADS评分(3.42±2.80)分较对照组的(6.13±3.33)分下降更显著,具有统计学差异(P<0.05)。两组患者出现轻度的腹泻、恶心呕吐,予对症处理后缓解,未影响后续治疗,两组患者药物不良反应发生率比较无显著差异性(P>0.05)。结论小建中汤联合匹维溴铵治疗脾虚型功能性消化不良EPS的效果好,安全性高。
Objective To investigate the efficacy and safety of Xiaojianzhong Decoction combined with pinaverium bromide in the treatment of functional dyspepsia(FD)epigastric pain syndrome(EPS)of spleen deficiency.Methods This study selected 48 patients with functional dyspepsia EPS of spleen deficiency type.They were divided into observation group(24 cases)and control group(24 cases)by random number table method.The observation group was given Xiaojianzhong Decoction+pinaverium bromide for treatment,and the control group was given pinaverium bromide for treatment.The Visual Analogue Scale(VAS)score,TCM symptom score,mental state[Hospital Anxiety and Depression Scale(HADS)score],and incidence of adverse drug reactions of the two groups were compared.Results After 4 weeks of treatment,the VAS scores in both groups decreased significantly.Moreover,the VAS score(1.29±1.23)points in the observation group decreased more significantly than the control group's(2.71±1.97)points,with a statistically significant difference(P<0.05).After 4 weeks of treatment,the TCM symptom scores in both groups decreased significantly.Moreover,the TCM symptom score(0.92±0.88)points in the observation group decreased more significantly than the control group's(1.88±1.54)points,with a statistically significant difference(P<0.05).After 4 weeks of treatment,the HADS scores in both groups decreased significantly.Moreover,the HADS score(3.42±2.80)points in the observation group decreased more significantly than the control group's(6.13±3.33)points,with a statistically significant difference(P<0.05).Both groups of patients experienced mild diarrhea,nausea,and vomiting,which resolved after symptomatic treatment and did not affect subsequent therapy.There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Xiaojianzhong Decoction combined with pinaverium bromide is effective and safe in the treatment of EPS of spleen deficiency type.
作者
李茹茹
LI Ru-ru(Department of Gastroenterology,Fuzhou Economic and Technological Development Zone Hospital,Fuzhou 350015,China)
出处
《中国现代药物应用》
2026年第3期23-26,共4页
Chinese Journal of Modern Drug Application
关键词
小建中汤
匹维溴铵
脾虚
功能性消化不良
上腹痛综合征
Xiaojianzhong Decoction
Pinaverium bromide
Spleen deficiency
Functional dyspepsia
Epigastric pain syndrome
