摘要
目的:收集近十年中医药治疗痰瘀阻络型缺血性中风临床用药数据,运用数据挖掘及Bron–Kerbosch(BK)算法探究其中药组方用药规律,为临床用药及机制研究提供理论基础。方法:检索各数据库中关于中医药治疗痰瘀阻络型缺血性中风临床用药的文献,收集符合纳入标准的中药组方并进行标准化处理,运用TCMNPAS平台及R语言,基于数据挖掘及BK算法等,探究其用药规律及核心组方。结果:共检索出文献230篇,纳入139篇,获得中药处方139首,涉及126味中药,每张处方平均用药味数为(12±3),总用药频次为1633次,核心组方多从肝论治,药物性味多苦、温,以祛痰化瘀为主要治则。结论:通过数据挖掘发现了治疗痰瘀阻络型缺血性中风主要以祛痰化瘀为治则,药物性味多苦、温。
Objective:To collect the clinical medication data of traditional Chinese medicine(TCM)in the treatment of the phlegm and blood stasis blocking meridians type ischemic stroke in the past decade,and to explore the medication rules of TCM prescription by data mining and Bron-Kerbosch(BK)algorithm,so as to provide a theoretical foundation for clinical medication and mechanism research.Methods:Relevant literature on the clinical medication of TCM in the treatment of the phlegm and blood stasis blocking meridians type ischemic stroke was retrieved from various databases,and the TCM prescriptions that met the inclusion criteria were collected and standardized.The TCMNPAS platform and R language were employed to investigate the medication rules and core prescriptions bases on data mining and BK algorithm.Results:A total of 230 articles were retrieved,and 139 were included after screening.There were 139 TCM prescriptions,involving 126 Chinese medicinal materials,with an average of(12±3)Chinese medicinal materials per prescription and a total medication frequency of 1633 times.The core prescription treated ischemic stroke mainly from the liver,with bitter in medicinal taste and warm in medicinal property Chinese medicinal materials as the main medicines,and phlegm-removing and blood stasis-eliminating as the primary therapeutic principles.Conclusion:Through data mining,it is found that the main therapeutic principle for the phlegm and blood stasis blocking meridians type ischemic stroke is to eliminate phlegm and remove blood stasis,and the medicinal property and medicinal taste of the included Chinese medicinal materials are mostly bitter and warm respectively.
出处
《中医临床研究》
2025年第25期41-49,共9页
Clinical Journal Of Chinese Medicine
基金
北京中医药大学青年教师资助项目(2024-BUCMXJKY031)。
