摘要
卵巢衰老是一组以卵巢功能进行性减退或过早衰竭为特征的妇科疾病,严重影响女性的生殖健康和生活质量。现代医学研究发现,线粒体功能障碍和肠道菌群失调与卵巢功能减退密切相关。线粒体作为细胞的能量工厂,其功能障碍直接影响卵巢细胞的能量供应,进而影响卵巢正常的生理功能。而肠道菌群失调则通过免疫、内分泌、慢性炎症等途径间接干扰卵巢功能。中医妇科学普遍从肾虚(阴阳两虚、肝肾阴虚)角度辨证论治,但临床许多患者伴随脾胃功能不足的情况。中医理论认为,脾胃为后天之本,可化生气血,滋养“先天生殖之精”及胞宫。现代研究证实,中医“脾”脏理论与线粒体、肠道菌群之间存在一定的联系。脾虚运化失职与线粒体产能效率低下、肠道菌群紊乱导致的营养吸收障碍和代谢废物堆积对应,且两者引发的慢性炎症恰似中医“湿浊内阻”困遏脾阳之象。健脾益气疗法或可通过优化线粒体功能、调节肠道菌群稳态对卵巢功能产生积极影响。这一过程与中医脾化生气血以滋养先天之精及胞宫相契合。鉴于此,本研究从“脾–线粒体–肠道菌群”的相关性入手,探讨“从脾论治”卵巢衰老。这不仅有助于丰富中医理论,还可能为临床治疗卵巢衰老提供更有效的中医药方案,为患者带来更多的治疗选择。
Ovarian aging refers to a group of gynecological disorders characterized by progressive decline or premature failure of ovarian function,significantly impacting women’s reproductive health and quality of life.Modern medical research has revealed that mitochondrial dysfunction and gut microbiota dysbiosis are closely associated with diminished ovarian function.Mitochondria are the energy factories of cells,and mitochondrial dysfunction directly impairs the energy supply for ovarian cells,affecting normal physiological function of ovary.Gut microbiota dysbiosis,meanwhile,indirectly interferes with ovarian function through immune,endocrine,and chronic inflammatory pathways.In traditional Chinese medicine(TCM)gynecology,ovarian aging is typically treated from the perspective of kidney deficiency[including both Yin(阴)and Yang(阳)deficiency,or liver-kidney Yin deficiency]based on syndrome differentiation.However,clinical practice reveals that many patients also exhibit insufficiency of spleen-stomach function.According to TCM theory,the spleen and stomach are the foundation of the body after birth,and are responsible for transforming food into Qi(气)and blood,which nourish the congenital reproductive essence and uterus.Modern research has confirmed that there is a certain connection between the concept of spleen in TCM and mitochondria as well as gut microbiota.Impaired transportation and transformation due to spleen deficiency corresponds to nutrient absorption disorders and metabolic waste accumulation caused by inefficient mitochondrial productivity and gut microbiota dysbiosis,and the chronic inflammation caused by both of them precisely aligns with the TCM concept of“dampness-turbidity internal obstruction”trapping spleen Yang.The therapy of fortifying the spleen and benefiting Qi may positively impact ovarian function by optimizing mitochondrial function and regulating gut microbiota homeostasis.This process is in line with the TCM principle of spleen generating Qi and blood to nourish the congenital essence and the uterus.In view of this,in this study,starting from the correlation of“spleen-mitochondria-intestinal microbiota”,treating ovarian aging from the perspective of spleen is explored.This approach can not only enrich the relevant theory in TCM,but also may offer more effective TCM strategies for clinical treatment of ovarian aging,providing expanded therapeutic options for patients.
出处
《中医临床研究》
2025年第26期27-33,共7页
Clinical Journal Of Chinese Medicine
基金
山东省中医药科技项目(M-2022017)。
关键词
卵巢衰老
从脾论治
线粒体
肠道菌群
Ovarian aging
Treatment from the perspective of spleen
Mitochondria
Gut microbiota
