摘要
银黄制剂解热抗炎、抗菌及抗病毒等作用显著,是治疗上呼吸道感染、咽炎和扁桃体炎的常用复方制剂。本文围绕银黄制剂化学成分、药理作用和临床应用展开综述,遵循中药质量标志物(quality marker,Q-marker)“五原则”分析预测该制剂的Q-marker,结果表明有机酸类物质(绿原酸、异绿原酸A、异绿原酸B和异绿原酸C)、环烯醚萜类物质(獐牙菜苷)黄酮类物质(黄芩苷、黄芩素、汉黄芩素、木犀草苷和汉黄芩苷)可以作为银黄制剂Q-marker,为银黄制剂物质基础和质量控制等后续研究提供科学参考。
Yinhuang preparations,with their significant anti-inflammatory,antibacterial,and antiviral properties,are widely utilized as compound formulations for the treatment of upper respiratory infections,pharyngitis,and tonsillitis.This paper provided a comprehensive review of the chemical composition,pharmacological actions,and clinical applications of the Yinhuang preparation,while also analyzing and predicting its quality markers(Q-markers)in accordance with the‘five principles’framework.The findings indicated that organic acids(including chlorogenic acid,isochlorogenic acid A,isochlorogenic acid B,and isochlorogenic acid C),iridoid terpenoids(such as sweroside),and flavonoids(namely baicalin,baicalein,wogonin and wogonoside)could serve as potential Q-markers for these preparations.This study offered valuable scientific insights for future research on the substance basis and quality control measures pertaining to Yinhuang preparations.
作者
周礼杰
张建锋
侯晓杰
侯长周
牟华刚
冯果
王建科
李玮
Zhou Lijie;Zhang Jianfeng;Hou Xiaojie;Hou Changzhou;Mou Huagang;Feng Guo;Wang Jianke;Li Wei(School of Pharmacy,Guizhou University of Traditional Chinese Medicine,Guiyang 550025;Guizhou Valid Pharmaceutical Co.LTD,Guiyang 550014;Guizhou Traditional Chinese Medicine Processing Technology Inheritance Base,Guiyang 550025)
出处
《中国抗生素杂志》
北大核心
2025年第11期1258-1268,共11页
Chinese Journal of Antibiotics
基金
贵州中医药大学研究生教育创新计划项目(No.YCXKYS2023034)
2024年全国老药工传承工作室建设项目(No.黔中医药函(2024)42号)
贵阳市中小企业发展专项资金(No.筑财工[2022]55号)。
关键词
银黄制剂
化学成分
药理作用
临床应用
质量标志物
Yinhuang preparation
Chemical composition
Pharmacological effects
Clinical application
Quality markers
