摘要
目的探讨可溶性CD14(sCD14)在鉴别细菌性与非细菌性腹泻中的应用价值。旨在研究sCD14在细菌性腹泻中的诊断效能。方法收集2024年9月至10月就诊于上海市东方医院/同济大学附属东方医院感染科门诊的57例急性腹泻患者,其中细菌性腹泻21例,非细菌性腹泻36例,对两组进行sCD14、C反应蛋白(CRP)、降钙素原(PCT)、血清淀粉样蛋白A(SAA)、白细胞介素-6(IL-6)和白细胞计数(WBC)及中性粒细胞百分比(NEUT%)检测,统计分析各炎症指标及联合诊断对于细菌性腹泻的诊断效能。结果sCD14、CRP、PCT、SAA、IL-6、WBC、NEUT%鉴别细菌性腹泻的曲线下面积(AUC)分别为0.703。sCD14联合CRP、PCT、SAA、IL-6、WBC、NEUT%鉴别细菌性腹泻的AUC分别为0.727。7项指标联合诊断AUC达0.804。sCD14鉴别细菌性腹泻的特异度为0.9706。sCD14联合CRP、PCT、SAA、IL-6、WBC、NEUT%鉴别细菌性腹泻的特异度可达0.8824。结论sCD14对细菌性腹泻诊断的特异性远高于PCT、IL-6、SAA、CRP等指标,sCD14联合现有炎症指标可为临床诊断细菌性腹泻提供重要价值。
Objective To explore the application value of soluble CD14(sCD14)in distinguishing bacterial and non bacterial diarrhea.Aim to investigate the diagnostic efficacy of sCD14 in bacterial diarrhea.Methods A total of 57 patients with acute diarrhea who visited theInfectious Diseases outpatient department in Shanghai East Hospital/The East Hospital Affiliated to Tongji University from September to October 2024 were collected,including 21 cases of bacterial diarrhea and 36 cases of non bacterial diarrhea.The two groups were tested for sCD14,C-reactive protein(CRP),procalcitonin(PCT),serum amyloid A(SAA),interleukin-6(IL-6),white blood cell count(WBC),and neutrophil percentage(NEUT%).The diagnostic efficacy of various inflammatory indicators and combined diagnosis for bacterial diarrhea was statistically analyzed.Results The areas under the curve(AUC)for distinguishing bacterial diarrhea using sCD14,CRP,PCT,SAA,IL-6,WBC,and NEUT%were 0.703,respectively.The AUC of sCD14 combined with CRP,PCT,SAA,IL-6,WBC,NEUT%for identifying bacterial diarrhea was 0.727,respectively.The combined diagnostic AUC of 7 indicators reached 0.804.The specificity of sCD14 in identifying bacterial diarrhea was 0.9706.The specificity of sCD14 combined with CRP,PCT,SAA,IL-6,WBC,NEUT%in identifying bacterial diarrhea could reach 0.8824.Conclusion The specificity of sCD14 in the diagnosis of bacterial diarrhea is much higher than indicators such as PCT,IL-6,SAA,CRP,etc.The combination of sCD14 and existing inflammatory indicators can provide important value for the clinical diagnosis of bacterial diarrhea.
作者
李志军
黄兆杰
李寒冰
袁茜茜
张晓飞
LI Zhijun;HUANG Zhaojie;LI Hanbing;YUAN Qianqian;ZHANG Xiaofei(Department of Laboratory Medicine,Shanghai East Hospital/The East Hospital Affiliated to Tongji University,Shanghai 200123,China;Shenzhen Mindray Biomedical Electronics Co.,Ltd.,Shenzhen,Guangdong 518063,China)
出处
《国际检验医学杂志》
2025年第S2期69-72,共4页
International Journal of Laboratory Medicine
关键词
可溶性CD14
细菌
腹泻
鉴别诊断
soluble CD14
bacteria
diarrhea
differential diagnosis
